Document Detail


Poly(2-Oxazoline)s - Are They More Advantageous for Biomedical Applications Than Other Polymers?
MedLine Citation:
PMID:  23034926     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Poly(2-alkyl-2-oxazoline)s are biocompatible polymers with polypeptide-isomeric structures that are attracting increasing interest as biomaterials for drug, gene, protein, and radionuclide delivery. They are, however, still relatively new in comparison to other classes of hydrophilic water-soluble polymers already established for such use, including poly(ethylene oxide), polyvinylpyrrolidone, and polymethacrylamides such as poly[N-(2-hydroxypropyl)methacrylamide]. This feature article critically compares the synthetic aspects and physicochemical and biological properties of poly(2-alkyl-2-oxazoline)s and these commonly studied polymers in terms of their suitability for biomedical applications.
Authors:
Ondrej Sedlacek; Bryn D Monnery; Sergey K Filippov; Richard Hoogenboom; Martin Hruby
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Macromolecular rapid communications     Volume:  33     ISSN:  1521-3927     ISO Abbreviation:  Macromol Rapid Commun     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9888239     Medline TA:  Macromol Rapid Commun     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1648-62     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Institute of Macromolecular Chemistry, v. v. i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic.
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