Document Detail


Poly (lactide-co-glycolide) nanoparticles containing coumarin-6 for suppository delivery: in vitro release profile and in vivo tissue distribution.
MedLine Citation:
PMID:  15371107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A delivery system consisting of the lipophilic fluorescent dye coumarin-6 embedded into polymer nanoparticles in a suppository base was formulated. Particle diameters of 400-1100 nm were produced by a salting-out method and measured by laser diffraction. Nanoparticles reach the systemic circulation via fenestrated capillaries or remain within rectal membranes to release their contents. Dissolution over 168 hr was initially rapid followed by a steady decline, and tissue distribution showed coumarin-6 to be present in liver and lungs for a similar time period while in kidney, small intestines, and blood up to 96 hr. Microscopic observations showed nanoparticles to be present in blood up to 72 hr.
Authors:
J G Eley; V D Pujari; J McLane
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug delivery     Volume:  11     ISSN:  1071-7544     ISO Abbreviation:  Drug Deliv     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-09-16     Completed Date:  2005-01-25     Revised Date:  2010-12-03    
Medline Journal Info:
Nlm Unique ID:  9417471     Medline TA:  Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, Florida 33416, USA. john_eley@pba.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Coumarins / administration & dosage*,  blood*,  chemistry
Drug Delivery Systems / methods*
Glycolates / administration & dosage*,  blood*,  chemistry
Male
Nanostructures* / chemistry
Rabbits
Suppositories
Tissue Distribution / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Coumarins; 0/Glycolates; 0/Suppositories; 0/polylactic acid-polyglycolic acid copolymer; 91-64-5/coumarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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