| Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine. | |
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MedLine Citation:
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PMID: 16789732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An antiapoptotic polymeric nanomedicine, PGA-peptoid 1, has been developed by the conjugation of a novel apoptotic protease activating factor 1 (Apaf-1) inhibitor (peptoid 1) to poly-L-glutamic acid (PGA). Full structural and biophysical characterization of the conjugate by different techniques has been accomplished. This macromolecule clearly enhances the antiapoptotic activity of peptoid 1 in different cell models. |
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Authors:
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María J Vicent; Enrique Pérez-Payá |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 49 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-22 Completed Date: 2006-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: United States |
Other Details:
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Languages: eng Pagination: 3763-5 Citation Subset: IM |
Affiliation:
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Department of Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Avenida Autopista del Saler, and Instituto de Biomedicina de Valencia, CSIC, E-46010 Valencia, Spain. mjvicent@cipf.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects* Apoptotic Protease-Activating Factor 1 Cell Line, Tumor Depression, Chemical Fibroblasts / cytology, drug effects Humans Intracellular Signaling Peptides and Proteins / antagonists & inhibitors* Mice Nanotechnology Peptoids / chemical synthesis*, chemistry, pharmacology Polyglutamic Acid / chemistry* Proteins / antagonists & inhibitors* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/APAF1 protein, human; 0/Apaf1 protein, mouse; 0/Apoptotic Protease-Activating Factor 1; 0/Intracellular Signaling Peptides and Proteins; 0/Peptoids; 0/Proteins; 25513-46-6/Polyglutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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