| Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury. | |
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MedLine Citation:
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PMID: 22086194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against ischemia modeled in vitro in brain cortical cells and in vivo in models of brain ischemia and renal ischemia. Further, unlike other Toll-like receptor (TLR) ligands, which generally induce significant inflammatory responses, poly-IC elicits only modest systemic inflammation. Results show that poly-IC is a new powerful prophylactic treatment that offers promise as a clinical therapeutic strategy to minimize damage in patient populations at risk of ischemic injury. |
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Authors:
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Amy E B Packard; Jason C Hedges; Frances R Bahjat; Susan L Stevens; Michael J Conlin; Andres M Salazar; Mary P Stenzel-Poore |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-11-16 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 32 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-02 Completed Date: 2012-03-21 Revised Date: 2012-05-08 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 242-7 Citation Subset: IM |
Affiliation:
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Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, physiopathology Brain Ischemia / physiopathology, prevention & control* Cells, Cultured Cytokines / blood Interferon Inducers / therapeutic use* Ischemic Preconditioning / methods* Kidney / drug effects, physiopathology Kidney Diseases / physiopathology, prevention & control* Male Mice Mice, Inbred C57BL Neuroprotective Agents / therapeutic use Poly I-C / therapeutic use* Reperfusion Injury / physiopathology, prevention & control* |
| Grant Support | |
ID/Acronym/Agency:
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NS050567/NS/NINDS NIH HHS; NS062381/NS/NINDS NIH HHS; R01 NS050567/NS/NINDS NIH HHS; R01 NS062381-04/NS/NINDS NIH HHS; T32A107472//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interferon Inducers; 0/Neuroprotective Agents; 24939-03-5/Poly I-C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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