| Poloxamer 188 failed to prevent exercise-induced membrane breakdown in mdx skeletal muscle fibers. | |
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MedLine Citation:
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PMID: 17118658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to determine the effectiveness of poloxamer 188 (P188) in protecting dystrophin-deficient, mdx skeletal muscle fiber membrane against exercise-induced breaches. mdx mice were treated with either P188 or placebo via intraperitoneal injections and run on a treadmill for 60-90 min. Membrane breakdown was quantified in cross-sections of rectus femoris muscle pretreated with Evans blue dye (in vivo). The mean % dye-penetrated muscle in the P188 and placebo groups was not significantly different in each of three trials. These results contrast with a recent report of P188 being highly effective in protecting the stretch- and dobutamine-stressed mdx heart muscle. The most likely explanations for the disparity are: (1) the exercise stress we used was beyond the protective range of P188, (2) P188 delivery and serum concentration were sub-optimal, or (3) the mdx skeletal myopathy and cardiomyopathy have fundamentally different responses to treatment. |
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Authors:
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John G Quinlan; Brenda L Wong; Richard T Niemeier; Alexandra S McCullough; Linda Levin; Martin Emanuele |
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Publication Detail:
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Type: Journal Article Date: 2006-11-21 |
Journal Detail:
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Title: Neuromuscular disorders : NMD Volume: 16 ISSN: 0960-8966 ISO Abbreviation: Neuromuscul. Disord. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2007-02-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9111470 Medline TA: Neuromuscul Disord Country: England |
Other Details:
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Languages: eng Pagination: 855-64 Citation Subset: IM |
Affiliation:
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Department of Neurology, The University of Cincinnati, 4010 Medical Science Building, Cincinnati, OH 45267-0525, USA. john.quinlan@uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomyopathies / drug therapy, metabolism, physiopathology Cell Membrane Permeability / drug effects*, physiology Coloring Agents Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Routes Exercise Tolerance / drug effects, physiology Female Injections, Intraperitoneal Male Mice Mice, Inbred C57BL Mice, Inbred mdx Muscle Contraction / drug effects, physiology Muscle Fibers, Skeletal / drug effects*, metabolism, pathology Muscle, Skeletal / drug effects*, metabolism, physiopathology Muscular Dystrophy, Duchenne / drug therapy*, metabolism, physiopathology Physical Conditioning, Animal / physiology Poloxamer / pharmacology*, therapeutic use Sarcolemma / drug effects*, metabolism Surface-Active Agents / pharmacology, therapeutic use Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Surface-Active Agents; 106392-12-5/Poloxamer |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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