Document Detail

Poloxamer 188 failed to prevent exercise-induced membrane breakdown in mdx skeletal muscle fibers.
MedLine Citation:
PMID:  17118658     Owner:  NLM     Status:  MEDLINE    
We sought to determine the effectiveness of poloxamer 188 (P188) in protecting dystrophin-deficient, mdx skeletal muscle fiber membrane against exercise-induced breaches. mdx mice were treated with either P188 or placebo via intraperitoneal injections and run on a treadmill for 60-90 min. Membrane breakdown was quantified in cross-sections of rectus femoris muscle pretreated with Evans blue dye (in vivo). The mean % dye-penetrated muscle in the P188 and placebo groups was not significantly different in each of three trials. These results contrast with a recent report of P188 being highly effective in protecting the stretch- and dobutamine-stressed mdx heart muscle. The most likely explanations for the disparity are: (1) the exercise stress we used was beyond the protective range of P188, (2) P188 delivery and serum concentration were sub-optimal, or (3) the mdx skeletal myopathy and cardiomyopathy have fundamentally different responses to treatment.
John G Quinlan; Brenda L Wong; Richard T Niemeier; Alexandra S McCullough; Linda Levin; Martin Emanuele
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Publication Detail:
Type:  Journal Article     Date:  2006-11-21
Journal Detail:
Title:  Neuromuscular disorders : NMD     Volume:  16     ISSN:  0960-8966     ISO Abbreviation:  Neuromuscul. Disord.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111470     Medline TA:  Neuromuscul Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  855-64     Citation Subset:  IM    
Department of Neurology, The University of Cincinnati, 4010 Medical Science Building, Cincinnati, OH 45267-0525, USA.
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MeSH Terms
Cardiomyopathies / drug therapy,  metabolism,  physiopathology
Cell Membrane Permeability / drug effects*,  physiology
Coloring Agents
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Routes
Exercise Tolerance / drug effects,  physiology
Injections, Intraperitoneal
Mice, Inbred C57BL
Mice, Inbred mdx
Muscle Contraction / drug effects,  physiology
Muscle Fibers, Skeletal / drug effects*,  metabolism,  pathology
Muscle, Skeletal / drug effects*,  metabolism,  physiopathology
Muscular Dystrophy, Duchenne / drug therapy*,  metabolism,  physiopathology
Physical Conditioning, Animal / physiology
Poloxamer / pharmacology*,  therapeutic use
Sarcolemma / drug effects*,  metabolism
Surface-Active Agents / pharmacology,  therapeutic use
Treatment Failure
Reg. No./Substance:
0/Coloring Agents; 0/Surface-Active Agents; 106392-12-5/Poloxamer

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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