Document Detail


Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.
MedLine Citation:
PMID:  18477449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. New techniques, including the application of small-molecule inhibitors, have greatly expanded our knowledge of the functions, targets, and regulation of this key mitotic enzyme. In this review, we focus on how Plk1 is recruited to centrosomes, kinetochores, and the spindle midzone and what the specific tasks of Plk1 at these distinct subcellular structures might be. In particular, we highlight new work on the role of Plk1 in cytokinesis in human cells. Finally, we describe how better understanding of Plk1 functions allows critical evaluation of Plk1 as a potential drug target for cancer therapy.
Authors:
Mark Petronczki; Péter Lénárt; Jan-Michael Peters
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Developmental cell     Volume:  14     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-14     Completed Date:  2008-05-29     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  646-59     Citation Subset:  IM    
Affiliation:
Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, United Kingdom. mark.petronczki@cancer.org.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle Proteins / metabolism*
Cytokinesis*
Humans
Kinetochores / enzymology
Mitosis*
Neoplasms / enzymology,  therapy
Protein Transport
Protein-Serine-Threonine Kinases / metabolism*
Proto-Oncogene Proteins / metabolism*
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Proto-Oncogene Proteins; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/polo-like kinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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