| Polish mother and child cohort study--defining the problem, the aim of the study and methodological assumption. | |
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MedLine Citation:
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PMID: 20053622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Exposures during prenatal period have implications for pregnancy outcome as well as for children's health, morbidity and mortality. Prospective cohort study design allows for the identification of exposures that may influence pregnancy outcome and children's health, verification of such exposures by biomarker measurements and notification of any changes in exposure level. MATERIALS AND METHODS: Polish Mother and Child Cohort Study (REPRO_PL) is multicenter prospective cohort study conducted in 8 different regions of Poland. The final cohort is intended to comprise 1300 mother-child pairs to be recruited within 4-year period (2007-2011). The recruitment and all scheduled visits are conducted in maternity units or clinics in the districts included in the study. The women are followed-up 3 times in pregnancy (once in each trimester) and after delivery for the notification of pregnancy outcome. During each visit, detailed questionnaire and biological samples are collected including saliva, urine, hair, maternal blood and cord blood. About 6 weeks postpartum, breast milk from part of the women is collected. The study concentrates on the identification and evaluation of the effects of prenatal environmental exposure on pregnancy outcome and children's health. Specific research hypotheses refer to the role of heavy metals, exposure to polycyclic aromatic hydrocarbons (PAHs) and environmental tobacco smoke (ETS) in the aetiology of small-for-gestational-age (SGA) and preterm delivery (PD). The role of oxidative stress putative mechanism and pregnant women nutritional status will be investigated. Based on questionnaire data, the impact of occupational exposures and stressful situations will be evaluated. RESULTS: The results of the study will become available within the next few years and will help to determine levels of child prenatal exposure in several areas of Poland and its impact on course and outcome of pregnancy. |
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Authors:
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Kinga Pola?ska; Wojciech Hanke; Jolanta Gromadzi?ska; Danuta Ligocka; Ewa Gulczy?ska; Wojciech Sobala; Wojciech W?sowicz |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of occupational medicine and environmental health Volume: 22 ISSN: 1232-1087 ISO Abbreviation: Int J Occup Med Environ Health Publication Date: 2009 |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9437093 Medline TA: Int J Occup Med Environ Health Country: Poland |
Other Details:
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Languages: eng Pagination: 383-91 Citation Subset: IM |
Affiliation:
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Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, ??d?, Poland. kinga@imp.lodz.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Chemical Analysis Cohort Studies* Female Fetal Development Hair / chemistry Humans Infant, Newborn Male Maternal Exposure / adverse effects* Milk, Human / chemistry Mothers* Oxidative Stress Poland Pregnancy Pregnancy Outcome* Prenatal Exposure Delayed Effects* Questionnaires Research Design* Saliva / chemistry Urinalysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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