Document Detail

Poliomyelitis and infantile paralysis: changes in host and virus.
MedLine Citation:
PMID:  7824688     Owner:  NLM     Status:  MEDLINE    
Death of motor neurones following invasion of the central nervous system by poliovirus may result in paralysis of specific muscles. Virulence may be tested by injection into monkeys by routes which bypass natural infection. Transmissibility is also very important, but cannot be measured, only inferred. An infection may lead to immunity or paralysis. In epidemics, the highest incidence among children 0-2 years was 2% and among those over 10 years was 25%: these figures fit a model of genetic susceptibility of homozygotes and heterozygotes with phenotypic susceptibility increasing with age. Hypogamma-globulinemics, some neonates and pregnant women are more susceptible than others. Intra-muscular injections may increase the risk of paralysis. Strenuous exercise and IM injections given when poliovirus has already reached the spinal cord can increase the severity of paralysis or convert a non-paralytic attack to paralysis. Although vaccines reduced polio in temperate countries, polio was thought to be no problem in the tropics. Since 1977 polio has been recognised as a massive problem in the third world: because it affects babies and very young children, it is properly infantile paralysis.
H V Wyatt
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  History and philosophy of the life sciences     Volume:  15     ISSN:  0391-9714     ISO Abbreviation:  Hist Philos Life Sci     Publication Date:  1993  
Date Detail:
Created Date:  1995-02-14     Completed Date:  1995-02-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8003052     Medline TA:  Hist Philos Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  357-96     Citation Subset:  IM; Q    
Dept. of Clinical Medicine, University of Leeds, U.K.
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MeSH Terms
Disease Models, Animal
Disease Susceptibility
History, 20th Century
Immunity, Innate
Models, Genetic
Poliomyelitis* / epidemiology,  etiology,  history,  virology
Poliovirus* / classification,  pathogenicity
Risk Factors

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