Document Detail

Polio trial: an early efficient clinical trial.
MedLine Citation:
PMID:  2189187     Owner:  NLM     Status:  MEDLINE    
The Salk Vaccine Field Trial was a randomized, placebo-controlled trial designed to test the efficacy of the Salk killed virus vaccine. Although the trial was not without some problems, both in design and analysis, none was important enough to raise serious questions about the results. Thus, the design of the Field Trial was well adapted to the demanding requirements. The trial owes its success in a large part to substantial public involvement. In designing future, large-scale, simple trials, we may still be able to benefit from the lessons of the Polio Vaccine Trial.
P Meier
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Publication Detail:
Type:  Clinical Trial; Historical Article; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Statistics in medicine     Volume:  9     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:    1990 Jan-Feb
Date Detail:
Created Date:  1990-06-29     Completed Date:  1990-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM; Q    
Department of Statistics, University of Chicago, IL 60637.
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MeSH Terms
History, 20th Century
Multicenter Studies as Topic
Poliovirus Vaccine, Inactivated / history*
Randomized Controlled Trials as Topic / history*
United States
Reg. No./Substance:
0/Poliovirus Vaccine, Inactivated

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