Document Detail


Polio trial: an early efficient clinical trial.
MedLine Citation:
PMID:  2189187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Salk Vaccine Field Trial was a randomized, placebo-controlled trial designed to test the efficacy of the Salk killed virus vaccine. Although the trial was not without some problems, both in design and analysis, none was important enough to raise serious questions about the results. Thus, the design of the Field Trial was well adapted to the demanding requirements. The trial owes its success in a large part to substantial public involvement. In designing future, large-scale, simple trials, we may still be able to benefit from the lessons of the Polio Vaccine Trial.
Authors:
P Meier
Related Documents :
21626347 - Allergen-specific immunotherapy: towards combination vaccines for allergic and infectio...
11899087 - Cellular and molecular mechanisms of vaccine-induced protection against retroviral infe...
9376207 - Evaluation of a video-supplement to informed consent: injection drug users and preventi...
15285707 - Poxvirus-based vaccine candidates for hiv: two decades of experience with special empha...
23113737 - Structural and functional characterization of the staphylococcus aureus virulence facto...
1910017 - Vaccination in murine schistosomiasis with adult worm-derived antigens: variables influ...
Publication Detail:
Type:  Clinical Trial; Historical Article; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Statistics in medicine     Volume:  9     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:    1990 Jan-Feb
Date Detail:
Created Date:  1990-06-29     Completed Date:  1990-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM; Q    
Affiliation:
Department of Statistics, University of Chicago, IL 60637.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Child
History, 20th Century
Humans
Multicenter Studies as Topic
Poliovirus Vaccine, Inactivated / history*
Randomized Controlled Trials as Topic / history*
United States
Chemical
Reg. No./Substance:
0/Poliovirus Vaccine, Inactivated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An evaluation of central laboratories in three VA cooperative studies.
Next Document:  A clinic's perspective on screening, recruitment and data collection.