Document Detail


Polarography and artificial neural network for the simultaneous determination of nalidixic acid and its main metabolite (7-hydroxymethylnalidixic acid).
MedLine Citation:
PMID:  18969303     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Nalidixic acid (NA) and its main metabolite, 7-hydroxymethylnalidixic acid (OH-NA), are simultaneously determined by applying artificial neural networks (ANNs), to their square wave voltammetric signals. The scores of a PCR model, built with the voltammetric data of a set of standard samples, recorded between -0.70 and -1.0V, are used as training set for the net for each compound. The trained nets (ANNs) are used for the simultaneous determination of NA and OH-NA in urine. The recovery values are comprised between 91 and 109% for NA and between 82 and 112% for OH-NA, being these results better than the results obtained by application of partial least squares (PLS) multivariate calibration.
Authors:
Agustina Guiberteau; Teresa Galeano Díaz; María I Rodríguez Cáceres; Juan M Ortiz Burguillos; Isabel Durán Merás; Francisco Salinas López
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Talanta     Volume:  62     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2012-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-65     Citation Subset:  -    
Affiliation:
Department of Analytical Chemistry, Faculty of Sciences, University of Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain.
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