Document Detail

Polarized sorting and trafficking in epithelial cells.
MedLine Citation:
PMID:  22525333     Owner:  NLM     Status:  MEDLINE    
The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the formation of an apical and a basolateral domain, which are separated by tight junctions. The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo molecules. This dynamic process involves the interaction of sorting signals with sorting machineries and the formation of transport carriers. Here we review the recent advances in the field of polarized sorting in epithelial cells. We especially highlight the role of lipid rafts in apical sorting.
Xinwang Cao; Michal A Surma; Kai Simons
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-24
Journal Detail:
Title:  Cell research     Volume:  22     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-04     Completed Date:  2012-08-31     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  793-805     Citation Subset:  IM    
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
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MeSH Terms
Biological Transport
Cell Polarity
Cell Tracking
Epithelial Cells / cytology*,  metabolism
Membrane Lipids / metabolism
Membrane Microdomains / metabolism
Membrane Proteins / metabolism
Reg. No./Substance:
0/Membrane Lipids; 0/Membrane Proteins

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