| Polarized sorting and trafficking in epithelial cells. | |
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MedLine Citation:
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PMID: 22525333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the formation of an apical and a basolateral domain, which are separated by tight junctions. The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo molecules. This dynamic process involves the interaction of sorting signals with sorting machineries and the formation of transport carriers. Here we review the recent advances in the field of polarized sorting in epithelial cells. We especially highlight the role of lipid rafts in apical sorting. |
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Authors:
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Xinwang Cao; Michal A Surma; Kai Simons |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-04-24 |
Journal Detail:
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Title: Cell research Volume: 22 ISSN: 1748-7838 ISO Abbreviation: Cell Res. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-04 Completed Date: 2012-08-31 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9425763 Medline TA: Cell Res Country: England |
Other Details:
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Languages: eng Pagination: 793-805 Citation Subset: IM |
Affiliation:
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Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Cell Polarity Cell Tracking Epithelial Cells / cytology*, metabolism Humans Membrane Lipids / metabolism Membrane Microdomains / metabolism Membrane Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Membrane Lipids; 0/Membrane Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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