Document Detail


Polarized light photography and videomicroscopy greatly enhance the capability of estimating the therapeuic response to a topical retinoid (adapalene) in acne vulgaris.
MedLine Citation:
PMID:  11845945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Assessment of improvement in acne lesions following treatment is often based on clinical evaluation and photographs. However, limitations are associated with this sublective evaluation, making it difficult to accurately review individual acne lesions and to observe early response to therapy. Conventional photographs do not allow us to visualize small lesions, and it can be difficult to differentiate inflammatory lesions as papules or small nodules. Our objective was to evaluate a new standardized method for tracking individual acne lesions based on photographs. The effect of adapalene gel 0.1% on both inflammatory and noninflammatory acne lesions was evaluated using this technique. Polarized light photography and videomicroscopy were used to record the evolution of acne lesions over a 16-week period in 5 volunteers with moderate acne vulgaris. During the first 4 weeks before treatment, acne lesions were evaluated on a 3-times weekly basis to establish a pattern of progression and determine the length of time to resolution. Sebum secretion rates were monitored using Sebutape adhesive patches applied to the forehead and both cheeks for 1 hour. After 4 weeks, adapalene gel 0.1% was used once daily at bedtime for 8 weeks; polarized light photography, videomicroscopy, and assessment of sebum production followed treatment response. This treatment period was followed by a further 4-week phase, after which acne lesions and sebum secretion rates were evaluated. Our results showed that the new methodology was appropriate to track acne lesions and allowed an accurate and more oblective evaluation of individual lesions. Using this methodology demonstrated that adapalene gel 0.1% causes rapid resolution of inflammatory and noninflammatory lesions. The probability of clearing inflammatory and noninflamma tory lesions during the treatment period increased, and the probability of new lesions appearing decreased. Sebum secretion rates declined in patients while on study drug, returning to near pretreatment levels following therapy cessation. Using sophisticated photography and videomicroscopy every other day proved to be a valuable, noninvasive, and reliable method of following response to adapalene treatment in patients with moderate acne vulgaris.
Authors:
E Rizova; P A Pagnoni; T Stoudemayer; M Poncet; A M Kligman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cutis     Volume:  68     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2002-02-15     Completed Date:  2002-08-12     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-33     Citation Subset:  IM    
Affiliation:
SKIN Incorporated, Conshohocken, Pennsylvania, USA.
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / diagnosis,  drug therapy*
Adolescent
Adult
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Dermatologic Agents / therapeutic use*
Female
Humans
Light
Male
Microscopy, Video / methods*
Naphthalenes / therapeutic use*
Photography / methods*
Sensitivity and Specificity
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Dermatologic Agents; 0/Naphthalenes; 1L4806J2QF/adapalene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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