Document Detail

Polarity proteins in migration and invasion.
MedLine Citation:
PMID:  19029938     Owner:  NLM     Status:  MEDLINE    
Cancer is the result of the deregulation of cell proliferation and cell migration. In advanced tumors, cells invade the surrounding tissue and eventually form metastases. This is particularly evident in carcinomas in which epithelial cells have undergone epithelial-mesenchymal transition. Increased cell migration often correlates with a weakening of intercellular interactions. Junctions between neighboring epithelial cells are required to establish and maintain baso-apical polarity, suggesting that not only loss of cell-cell adhesion but also alteration of cell polarity is involved during invasion. Accordingly, perturbation of cell polarity is an important hallmark of advanced invasive tumors. Cell polarity is also essential for cell migration. Indeed, a front-rear polarity axis has first to be generated to allow a cell to migrate. Because cells migrate during invasion, cell polarity is not completely lost. Instead, polarity is modified. From a nonmigrating baso-apically polarized epithelial phenotype, cells acquire a polarized migrating mesenchymal phenotype. The aim of this review is to highlight the molecular relationship between the control of cell polarity and the regulation of cell motility during oncogenesis.
S Etienne-Manneville
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Oncogene     Volume:  27     ISSN:  1476-5594     ISO Abbreviation:  Oncogene     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  6970-80     Citation Subset:  IM    
Cell polarity and migration group, Institut Pasteur and CNRS URA 2582, Paris cedex 15, France.
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MeSH Terms
Cell Adhesion / genetics,  physiology
Cell Movement / genetics,  physiology*
Cell Polarity* / genetics,  physiology
Epithelial Cells / metabolism,  physiology
Membrane Proteins / genetics,  metabolism,  physiology*
Models, Biological
Neoplasm Invasiveness / genetics,  physiopathology*
Oncogenes / physiology
Protein Transport / genetics,  physiology
Signal Transduction / genetics,  physiology
Reg. No./Substance:
0/Membrane Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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