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Polarcath cryoplasty enhances smooth muscle cell apoptosis in a rabbit iliac artery model: An experimental in vivo controlled study.
MedLine Citation:
PMID:  21982952     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To in vivo investigate the histological response after single and double cryoplasty therapy in a rabbit iliac artery model. MATERIALS AND METHODS: In total, 40 New Zealand White rabbits underwent percutaneous transluminal angioplasty of the iliac artery using either PolarCath balloon or a conventional angioplasty balloon of equal diameter. Arterial injury, inflammatory response and smooth muscle cells (SMC) apoptosis with the TUNEL (Terminal deoxynucleotidyl transferase dUTP Nick End Labeling) immunohistochemical assay were analyzed. Rabbits were divided between single or double balloon inflation and histological results were compared between cryoplasty and control angioplasty both at 30min and 72h. RESULTS: Arterial injury and wall inflammation scores were low and similar between cryoplasty and control groups after single and double balloon inflation. Compared to conventional balloon angioplasty, Polarcath cryoplasty demonstrated superior SMC apoptosis after single inflation at 30min [12.0±1.2cells/(0.025mm)2 vs 7.0±1.5cells/(0.025mm)2, p=0.002], single inflation at 72h [9.0±1.0cells/(0.025mm)(2) vs 5.4±1.4cells/(0.025mm)(2), p=0.001], double inflation at 30min [11.6±1.5cells/(0.025mm)(2) vs 6.8±1.4cells/(0.025mm)(2), p=0.001] and double inflation at 72h [9.2±0.8cells/(0.025mm)(2) vs 5.0±0.7cells/(0.025mm)(2), p=0.001]. There were no significant differences in apoptosis between single and double cryoplasty application at 30min and 72h. CONCLUSION: Cryoplasty demonstrated superior rates of SMC apoptosis at 30min and 72h and was associated to relatively low arterial injury and inflammation scores. An immediate second PolarCath inflation did not achieve superior apoptosis.
Authors:
Stavros Spiliopoulos; Athanasios Diamantopoulos; Konstantinos Katsanos; Panagiota Ravazoula; Dimitrios Karnabatidis; Dimitrios Siablis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-29
Journal Detail:
Title:  Cryobiology     Volume:  -     ISSN:  1090-2392     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006252     Medline TA:  Cryobiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Department of Radiology, School of Medicine, Patras University Hospital, Rion, GR 26504, Greece.
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