Document Detail

Polar opposites: Fine-tuning cytokinesis through SIN asymmetry.
MedLine Citation:
PMID:  22786806     Owner:  NLM     Status:  MEDLINE    
Mitotic exit and cell division must be spatially and temporally integrated to facilitate equal division of genetic material between daughter cells. In the fission yeast, Schizosaccharomyces pombe, a spindle pole body (SPB) localized signaling cascade termed the septation initiation network (SIN) couples mitotic exit with cytokinesis. The SIN is controlled at many levels to ensure that cytokinesis is executed once per cell cycle and only after cells segregate their DNA. An interesting facet of the SIN is that its activity is asymmetric on the two SPBs during anaphase; however, how and why the SIN is asymmetric has remained elusive. Many key factors controlling SIN asymmetry have now been identified, shedding light on the significance of SIN asymmetry in regulating cytokinesis. In this review, we highlight recent advances in our understanding of SIN regulation, with an emphasis on how SIN asymmetry is achieved and how this aspect of SIN regulation fine-tunes cytokinesis.
Alyssa E Johnson; Dannel McCollum; Kathleen L Gould
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-11
Journal Detail:
Title:  Cytoskeleton (Hoboken, N.J.)     Volume:  69     ISSN:  1949-3592     ISO Abbreviation:  Cytoskeleton (Hoboken)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-23     Completed Date:  2013-03-21     Revised Date:  2014-07-24    
Medline Journal Info:
Nlm Unique ID:  101523844     Medline TA:  Cytoskeleton (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  686-99     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Cell Polarity*
Schizosaccharomyces / cytology*,  genetics,  metabolism*
Schizosaccharomyces pombe Proteins / metabolism*
Signal Transduction*
Spindle Apparatus / metabolism
Grant Support
GM058406/GM/NIGMS NIH HHS; R01 GM058406/GM/NIGMS NIH HHS; T32 GM08554/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Schizosaccharomyces pombe Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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