Document Detail

Poisoning by Coriaria myrtifolia Linnaeus: a new case report and review of the literature.
MedLine Citation:
PMID:  16165183     Owner:  NLM     Status:  MEDLINE    
Coriaria myrtifolia should be recognized as one of the most neurotoxic plants in western Mediterranean area. This shrub produces a toxin, coriamyrtin, that is present in high concentrations in the berries. Ingestion of few fruits similar to blackberries may induce digestive and neurological manifestations including seizures, coma and apnea. The authors present a new case report that took place in the French Catalonia: an 8 year-old boy developed vomiting and generalized recurrent convulsions after ingestion of C. myrtifolia berries. He needed repeated diazepam administrations and was managed in the hospital. He recovered after one day of benzodiazepine treatment. In order to evaluate the consequences of C. myrtifolia poisoning, 83 cases of the literature were analyzed: the cases occurred in three countries (Spain, France and Morocco); the mean delay of the symptom development was 150 min; the neurological disturbances were the most frequent signs and 11 patients died (6 children, 5 adults) mainly in old reports.
Luc de Haro; Philip Pommier; Lucia Tichadou; Maryvonne Hayek-Lanthois; Jocelyne Arditti
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2005-09-12
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  46     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-11     Completed Date:  2006-06-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  600-3     Citation Subset:  IM    
Toxicovigilance, Poison Control Centre, Centre Antipoison, Hôpital Salvator, 249 boulevard Sainte Marguerite, 13009 Marseille, France.
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MeSH Terms
Angiosperms / chemistry*
Benzodiazepines / therapeutic use*
Clonazepam / therapeutic use
Fruit / chemistry,  toxicity*
Lactones / toxicity*
Plant Poisoning / drug therapy*,  pathology*
Plants, Toxic / chemistry
Time Factors
Reg. No./Substance:
0/Lactones; 124-87-8/Picrotoxin; 12794-10-4/Benzodiazepines; 1622-61-3/Clonazepam; 2571-86-0/coriamyrtine

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