Document Detail

Point and interval estimation of primary and secondary parameters in a two-stage adaptive clinical trial.
MedLine Citation:
PMID:  18327717     Owner:  NLM     Status:  MEDLINE    
Investigated in this paper is the point estimation and confidence intervals of the treatment efficacy parameter and related secondary parameters in a two-stage adaptive trial. Based on the minimal sufficient statistics, several alternative estimators to the sample averages are proposed to reduce the bias and to improve the precision of estimation. Confidence intervals are constructed using Woodroofe's pivot method. Numerical studies are conducted to evaluate the bias and mean squared error of the estimators and the coverage probability of the confidence intervals.
Aiyi Liu; Chengqing Wu; Kai F Yu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Journal of biopharmaceutical statistics     Volume:  18     ISSN:  1520-5711     ISO Abbreviation:  J Biopharm Stat     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200436     Medline TA:  J Biopharm Stat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211-26     Citation Subset:  IM    
Department of Health and Human Services, Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, Rockville, Maryland 20852, USA.
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MeSH Terms
Clinical Trials as Topic / methods,  statistics & numerical data*
Confidence Intervals*
Endpoint Determination
Models, Statistical*
Sample Size

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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