Document Detail

Poikiloderma-like lesions on the neck in atopic dermatitis: a histopathological study.
MedLine Citation:
PMID:  2329225     Owner:  NLM     Status:  MEDLINE    
Reticulate pigmentation with or without skin atrophy, depigmentation and telangiectasia is frequently encountered on the neck of severe cases of adult type atopic dermatitis. These skin changes were graded clinically into 3 stages. Based on histological features, hyperplasia of the sebaceous gland, dilated tortuous capillaries, and mild degeneration of elastic fibers were noted in stage I lesions. Lesions of both stages II and III contained increased melanin in the basal cell layer with incontinence of pigment, remarkable destruction and degeneration of elastic fibers, proliferated and dilated capillaries, and deposition of mucinous substances. The numbers of mast cells in papillary dermis were significantly increased in late stage I and stage II lesions. Poikiloderma-like lesions on the neck could be attributable to chronic inflammation and delay of wound healing process, possibly caused by long-standing topical corticosteroid therapy.
H Mukai; K Nishioka; K Kamimura; I Katayama; S Nishiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  17     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-25     Completed Date:  1990-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.
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MeSH Terms
Cell Count
Dermatitis, Atopic / complications,  pathology*
Mast Cells / pathology
Pigmentation Disorders / etiology,  pathology*
Skin / pathology*

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