| Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines. | |
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MedLine Citation:
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PMID: 23047035 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Human podoplanin is a type-1 transmembrane sialomucin-like glycoprotein that is involved in cell migration, tumor cell invasion and metastasis. Our recent study of oral squamous cell carcinoma (OSCC) demonstrated that the degree of immunohistochemical expression of podoplanin was correlated with the severity of epithelial dysplasia and significantly associated with a poor pathologic grade of differentiation. Furthermore, it has been reported that Src directly associates with the epidermal growth factor receptor (EGFR) in OSCC cells upon stimulation with EGF and phosphorylates Crk-associated substrate (Cas), podoplanin acting downstream of Src and Cas to promote cell migration. However, the molecular function of podoplanin remains unclear. In this study we performed real-time RT-PCR, Western blotting and scratch assay using OSCC cell lines in order to clarify the molecular biological function of podoplanin expression associated with various growth factors including EGF and with the Src-Cas signaling pathway. Podoplanin was found to have a marked influence on cancer cell migration and the expression of matrix metalloprotease-9 (MMP-9) in the oral cavity upon stimulation with EGF. Podoplanin promotes oral cancer cell migration, and the EGF-Src-Cas pathway is one of the possible mechanisms responsible for progression of cancer in the oral cavity. (J Oral Sci 54, 241-250, 2012). |
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Authors:
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Harumi Inoue; Yuji Miyazaki; Kentaro Kikuchi; Noriaki Yoshida; Fumio Ide; Yoshihiro Ohmori; Akihito Tomomura; Hideaki Sakashita; Kaoru Kusama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of oral science Volume: 54 ISSN: 1880-4926 ISO Abbreviation: J Oral Sci Publication Date: 2012 |
Date Detail:
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Created Date: 2012-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808942 Medline TA: J Oral Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 241-50 Citation Subset: D; IM |
Affiliation:
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Division of Pathology, Department of Diagnostic & Therapeutic Sciences, Meikai University School of Dentistry. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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