| Podocyte research in rheumatic diseases. | |
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MedLine Citation:
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PMID: 21372512 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Podocytes are glomerular visceral epithelial cells, which function as molecular sieve with foot process (FT) and slit diaphragm (SD) spanning FT, not to allow high molecular weight protein to be filtrated through glomerular capillary loop. Pathological proteinuria is caused by discoordinated tertiary podocyte structure such as disappearance of FT and/or SD, and irreversible glomeular sclerosis is caused by podocyte loss due to cell death and/or detachment from capillary wall. With recent advance of nephrological research technology such as podocyte cell culture system, genetically engineered transgenic mice with podocyte-specific regulation of gene expression, podocyte-associated biomarkers, the new isolation method of glomeruli, laser capture microdissection, multiphoton imaging and extracellular flux analyzer, new findings of pathogenesis of glomerular lesions will be expected, not only in primary glomerulonephritis, but also in secondary glomerulonephritis or glomerulopathy due to rheumatic diseases. |
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Authors:
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Hiroshi Kajiyama |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology Volume: 34 ISSN: 1349-7413 ISO Abbreviation: Nihon Rinsho Meneki Gakkai Kaishi Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505992 Medline TA: Nihon Rinsho Meneki Gakkai Kaishi Country: Japan |
Other Details:
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Languages: eng Pagination: 40-8 Citation Subset: IM |
Affiliation:
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Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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