| Podocyte phenotypes as defined by expression and distribution of GLEPP1 in the developing glomerulus and in nephrotic glomeruli from MCD, CNF, and FSGS. A dedifferentiation hypothesis for the nephrotic syndrome. | |
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MedLine Citation:
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PMID: 9639039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glomerular epithelial protein 1 (GLEPP1) is a podocyte receptor membrane protein tyrosine phosphatase located on the apical cell membrane of visceral glomerular epithelial cell (VGEC) foot processes. Double label immunofluorescence, immunoelectron microscopy, and peroxidase immunohistochemistry were used to map the GLEPP1 distribution in the developing glomerulus and in minimal-change nephropathy (MCN), congenital nephrotic syndrome of the Finnish type, and focal-segmental glomerulosclerosis (FSGS). In MCN GLEPP1 was shifted away from the glomerular basement membrane on the apical cell membrane of effaced foot processes. These data are compatible with the previously suggested concept that MCN can be considered a form of dedifferentiation of the podocyte phenotype. Similarly, changes seen in congenital nephrotic syndrome of the Finnish type can be considered a consequence of failure to complete normal podocyte development. In FSGS glomeruli GLEPP1 was frequently absent from VGECs, even when no sclerosis was detectable in that glomerulus. Therefore, in FSGS, VGECs may lose GLEPP1, and this loss appears to occur in the absence of scarring and may, therefore, precede the scarring process. We speculate that a changed VGEC phenotype that does not express GLEPP1 might have properties similar to the early undifferentiated VGEC developmental phenotype. GLEPP1 distribution pattern and absence from glomeruli of individuals with nephrotic syndrome may, therefore, represent a useful phenotypic marker. |
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Authors:
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K Sharif; M Goyal; D Kershaw; R Kunkel; R Wiggins |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental nephrology Volume: 6 ISSN: 1018-7782 ISO Abbreviation: Exp. Nephrol. Publication Date: 1998 May-Jun |
Date Detail:
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Created Date: 1998-08-17 Completed Date: 1998-08-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9302239 Medline TA: Exp Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 234-44 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Michigan, Ann Arbor, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Antibodies, Monoclonal Biological Markers Fluorescent Antibody Technique Glomerulosclerosis, Focal Segmental / metabolism, pathology* Humans Immunoenzyme Techniques Immunophenotyping Kidney Glomerulus / chemistry*, embryology*, ultrastructure Membrane Proteins / analysis*, genetics, immunology Mice Microscopy, Immunoelectron Nephrosis, Lipoid / metabolism, pathology Nephrotic Syndrome / metabolism, pathology* Phenotype Protein Tyrosine Phosphatases / analysis*, genetics, immunology Rabbits Receptor-Like Protein Tyrosine Phosphatases, Class 3 |
| Grant Support | |
ID/Acronym/Agency:
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DK39255/DK/NIDDK NIH HHS; DK46073/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Biological Markers; 0/Membrane Proteins; EC 3.1.3.48/PTPRO protein, human; EC 3.1.3.48/Protein Tyrosine Phosphatases; EC 3.1.3.48/Ptpro protein, mouse; EC 3.1.3.48/Receptor-Like Protein Tyrosine Phosphatases, Class 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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