Document Detail

Podocyte detachment in type 2 diabetic nephropathy.
MedLine Citation:
PMID:  21659731     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Glomerular podocyte number declines and urinary excretion of podocytes increases as kidney disease progresses in persons with type 2 diabetes mellitus (T2DM).
METHODS: Using high-power electron microscopy, we quantified podocyte detachment in T2DM.
RESULTS: We evaluated 106 glomeruli (range 1-6 per subject) from 40 Pima Indian subjects with T2DM enrolled in a clinical trial. On high-power electron micrographs, 35% of the subjects had no evidence of podocyte detachment. Among the remaining subjects, the median percentage of basement membrane with podocyte detachment was 0.62% (interquartile range = 0.32-1.52%).
CONCLUSION: Podocyte detachment from the glomerular basement membrane has been described and measured in type 1 diabetes mellitus using a different method. We now document podocyte detachment microscopically and quantify it morphometrically in humans with T2DM. The findings offer quantitative histologic support to a potential mechanism for the functional impairment, and possibly the sclerosis of glomeruli, in diabetic glomerular injury.
E Jennifer Weil; Kevin V Lemley; Berne Yee; Tracy Lovato; Meghan Richardson; Bryan D Myers; Robert G Nelson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2011-06-10
Journal Detail:
Title:  American journal of nephrology     Volume:  33 Suppl 1     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-10     Completed Date:  2011-10-19     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
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MeSH Terms
Basement Membrane / pathology*,  ultrastructure
Cell Adhesion
Diabetes Mellitus, Type 2 / complications,  ethnology
Diabetic Nephropathies / ethnology,  etiology,  pathology*
Histological Techniques
Indians, North American
Microscopy, Electron
Middle Aged
Podocytes / pathology*,  ultrastructure

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