| Podocyte detachment in type 2 diabetic nephropathy. | |
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MedLine Citation:
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PMID: 21659731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Glomerular podocyte number declines and urinary excretion of podocytes increases as kidney disease progresses in persons with type 2 diabetes mellitus (T2DM). METHODS: Using high-power electron microscopy, we quantified podocyte detachment in T2DM. RESULTS: We evaluated 106 glomeruli (range 1-6 per subject) from 40 Pima Indian subjects with T2DM enrolled in a clinical trial. On high-power electron micrographs, 35% of the subjects had no evidence of podocyte detachment. Among the remaining subjects, the median percentage of basement membrane with podocyte detachment was 0.62% (interquartile range = 0.32-1.52%). CONCLUSION: Podocyte detachment from the glomerular basement membrane has been described and measured in type 1 diabetes mellitus using a different method. We now document podocyte detachment microscopically and quantify it morphometrically in humans with T2DM. The findings offer quantitative histologic support to a potential mechanism for the functional impairment, and possibly the sclerosis of glomeruli, in diabetic glomerular injury. |
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Authors:
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E Jennifer Weil; Kevin V Lemley; Berne Yee; Tracy Lovato; Meghan Richardson; Bryan D Myers; Robert G Nelson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2011-06-10 |
Journal Detail:
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Title: American journal of nephrology Volume: 33 Suppl 1 ISSN: 1421-9670 ISO Abbreviation: Am. J. Nephrol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-10 Completed Date: 2011-10-19 Revised Date: 2012-06-19 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 21-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arizona Basement Membrane / pathology*, ultrastructure Cell Adhesion Diabetes Mellitus, Type 2 / complications, ethnology Diabetic Nephropathies / ethnology, etiology, pathology* Female Histological Techniques Humans Indians, North American Male Microscopy, Electron Middle Aged Podocytes / pathology*, ultrastructure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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