Document Detail

Pneumonitis related to docetaxel: case report and review of the literature.
MedLine Citation:
PMID:  19567400     Owner:  NLM     Status:  MEDLINE    
Taxotere has recently been making a noticeable impact on breast, gastric, ovarian, prostate and non-small cell lung cancers. Its side effects include dyspnea, pruritus, skin rashes, fever and hypotension. The patient presented the less common, however potentially fatal, toxicity of pneumonitis. He initially presented with a flu-like illness and hypoxia that was unresponsive to antibiotic treatment and actually progressed. He presented 14 days after his second dose of taxotere, although in retrospect noted symptoms several days prior. Although some patients described in the literature have progressed to respiratory failure requiring mechanical ventilation, this patient responded to steroid treatment and withdrawal of taxotere.
Susan Alsamarai; Andriani G Charpidou; Richard A Matthay; Daniel Confeld; Kostas N Syrigos; Muhammad W Saif
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  23     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-07-01     Completed Date:  2009-09-24     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  635-7     Citation Subset:  IM    
Department of Clinical Oncology, Yale Univeristy School of Medicine, New Haven, CT, U.S.A.
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MeSH Terms
Adenocarcinoma / drug therapy*
Antineoplastic Agents / adverse effects*
Esophageal Neoplasms / drug therapy*
Pneumonia / chemically induced*,  radiography
Taxoids / adverse effects*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Taxoids; 15H5577CQD/docetaxel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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