Document Detail


Pneumonitis induced by rifampicin: a case report and literature review.
MedLine Citation:
PMID:  23411704     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
An 84-year-old woman being treated for miliary tuberculosis (TB) with rifampicin (RFP), isoniazid (INH), ethambutol (EB) and corticosteroids suffered from a persistent fever for five months. While tapering the dose of prednisolone, chest computed tomography (CT) revealed diffuse ground glass opacities (GGO) and bronchoalveolar lavage fluid (BALF) showed an increase in lymphocytes. After the anti-TB drugs were discontinued and the dose of the corticosteroids was increased, the CT findings and fever improved considerably. However, readministration of RFP provoked an inflammatory reaction, leading to a diagnosis of RFP-induced pneumonitis. This condition is very rare. This is the first report of RFP-induced pneumonitis occurring during adjunct steroid therapy.
Authors:
Yasuko Koma; Keiko Goto; Chihiro Yoshida; Kengo Kimura; Yusuke Matsumoto; Midori Koyama; Nariyasu Nakashima; Daiki Masuya; Hirofumi Matsuoka; Harukazu Yoshimatsu; Yujiro Suzuki
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Publication Detail:
Type:  Journal Article     Date:  2013-02-15
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  52     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Affiliation:
Respiratory Center, Shinko Hospital, Japan.
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