Document Detail


Pneumonic pasteurellosis induced experimentally in gnotobiotic and conventional calves inoculated with Pasteurella haemolytica.
MedLine Citation:
PMID:  2240809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimental pneumonia caused by Pasteurella haemolytica was induced in 2-week-old gnotobiotic (n = 4) and conventional (n = 6) calves by endobronchial inoculation into the right caudal lung lobe of 7.9 x 10(10) +/- 0.6 x 10(10) (mean +/- SD) colony-forming units of P haemolytica in the 6-hour log phase of growth. The calves were studied for 24 hours or less. Regression lines for the relationship between clinical index and time for the gnotobiotic group and conventional group of calves were compared, and the clinical index was found to be significantly (P less than or equal to 0.005) more rapid in the gnotobiotic group. There was also a significant difference in the preinoculation, absolute segmented neutrophil count (P less than or equal to 0.05), and in the total serum protein, albumin, and globulin values (P less than or equal to 0.05). Comparison of the preinoculation and post inoculation blood cell and blood chemical values revealed a significant increase (P less than or equal to 0.05) in the numbers of band neutrophils and fibrinogen in conventional calves, and a significant decrease (P less than or equal to 0.05) in the total WBC count in gnotobiotic calves. Necropsy of both groups of calves revealed a circular to oblong lesion that was congested, edematous, and firm, and which occupied 20% to 100% of the right caudal lung lobe and involved the remaining lung lobes to a more minor degree. When mean lesion scores of the 2 groups of calves were compared, no significant difference (P less than or equal to 0.05) was found.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J G Vestweber; R D Klemm; H W Leipold; D E Johnson
Related Documents :
2917929 - Induction of alveolar epithelial injury by phospholipase a2.
11872119 - Bacteria in heart and lungs of young chicks.
22458699 - The effect of warm up on single and intermittent-sprint performance.
11572929 - Mechanisms of surfactant exocytosis in alveolar type ii cells in vitro and in vivo.
21198979 - Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of...
18591759 - Trunk position influences the kinematics, kinetics, and muscle activity of the lead low...
23029969 - Influence of deep breathing exercise on spontaneous respiratory rate and heart rate var...
8430919 - Preventive effect and duration of action of disodium cromoglycate and procaterol on exe...
18470379 - Oxygen demand during mineralization of aquatic macrophytes from an oxbow lake.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  51     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-24     Completed Date:  1990-12-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1799-805     Citation Subset:  IM    
Affiliation:
Department of Surgery and Medicine, College of Veterinary Medicine, Kansas State University, Manhattan 66506.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Cattle Diseases / etiology*,  microbiology,  pathology
Female
Fibrin / biosynthesis
Germ-Free Life*
Lung Diseases / pathology,  veterinary*
Male
Pasteurella / growth & development,  pathogenicity
Pasteurellosis, Pneumonic / etiology*,  microbiology,  pathology
Pulmonary Edema / pathology,  veterinary
Time Factors
Chemical
Reg. No./Substance:
9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical and pathologic studies of experimentally induced Pasteurella haemolytica pneumonia in calve...
Next Document:  Effect of in-house transport on murine plasma corticosterone concentration and blood lymphocyte popu...