Document Detail

Pneumonic pasteurellosis induced experimentally in gnotobiotic and conventional calves inoculated with Pasteurella haemolytica.
MedLine Citation:
PMID:  2240809     Owner:  NLM     Status:  MEDLINE    
Experimental pneumonia caused by Pasteurella haemolytica was induced in 2-week-old gnotobiotic (n = 4) and conventional (n = 6) calves by endobronchial inoculation into the right caudal lung lobe of 7.9 x 10(10) +/- 0.6 x 10(10) (mean +/- SD) colony-forming units of P haemolytica in the 6-hour log phase of growth. The calves were studied for 24 hours or less. Regression lines for the relationship between clinical index and time for the gnotobiotic group and conventional group of calves were compared, and the clinical index was found to be significantly (P less than or equal to 0.005) more rapid in the gnotobiotic group. There was also a significant difference in the preinoculation, absolute segmented neutrophil count (P less than or equal to 0.05), and in the total serum protein, albumin, and globulin values (P less than or equal to 0.05). Comparison of the preinoculation and post inoculation blood cell and blood chemical values revealed a significant increase (P less than or equal to 0.05) in the numbers of band neutrophils and fibrinogen in conventional calves, and a significant decrease (P less than or equal to 0.05) in the total WBC count in gnotobiotic calves. Necropsy of both groups of calves revealed a circular to oblong lesion that was congested, edematous, and firm, and which occupied 20% to 100% of the right caudal lung lobe and involved the remaining lung lobes to a more minor degree. When mean lesion scores of the 2 groups of calves were compared, no significant difference (P less than or equal to 0.05) was found.(ABSTRACT TRUNCATED AT 250 WORDS)
J G Vestweber; R D Klemm; H W Leipold; D E Johnson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  51     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-24     Completed Date:  1990-12-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1799-805     Citation Subset:  IM    
Department of Surgery and Medicine, College of Veterinary Medicine, Kansas State University, Manhattan 66506.
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MeSH Terms
Cattle Diseases / etiology*,  microbiology,  pathology
Fibrin / biosynthesis
Germ-Free Life*
Lung Diseases / pathology,  veterinary*
Pasteurella / growth & development,  pathogenicity
Pasteurellosis, Pneumonic / etiology*,  microbiology,  pathology
Pulmonary Edema / pathology,  veterinary
Time Factors
Reg. No./Substance:

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