| Pneumocystis jirovecii infection: Cell wall (1→3)-β-D-glucan biology and diagnostic utility. | |
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MedLine Citation:
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PMID: 20854193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pneumocystis jirovecii has emerged as an important pulmonary pathogen. Historically associated with the immunocompromised, it is being increasingly observed in immunocompetent populations. (1→3)-ß-D-glucan (BG) is a major component of the cyst cell wall and plays an important role in the inflammatory response to the organism. Inflammatory synergy by co-stimulation with BG and Toll-like receptor ligands has been demonstrated in vitro and may be a factor in the pathophysiology of Pneumocystis pneumonia. Detection of highly elevated serum concentrations of BG in the serum of patients has been shown to be highly sensitive for the presence of pulmonary P. jirovecii. |
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Authors:
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Malcolm A Finkelman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical reviews in microbiology Volume: 36 ISSN: 1549-7828 ISO Abbreviation: Crit. Rev. Microbiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8914274 Medline TA: Crit Rev Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 271-81 Citation Subset: IM |
Affiliation:
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Associates of Cape Cod, Inc., East Falmouth, MA 02536, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Wall
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chemistry Female Humans Immunocompromised Host Male Pneumocystis jirovecii / cytology, pathogenicity* Pneumonia, Pneumocystis / diagnosis*, immunology, microbiology* Toll-Like Receptors / immunology, metabolism beta-Glucans / blood, diagnostic use*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Toll-Like Receptors; 0/beta-Glucans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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