Document Detail

Pneumocystis carinii pneumonia in a term newborn infant with a transiently depressed T lymphocyte count, primarily of cells carrying the CD4 antigen.
MedLine Citation:
PMID:  8496763     Owner:  NLM     Status:  MEDLINE    
A term infant without infection by human immunodeficiency virus had pneumocystis pneumonia at 17 days of life. Initial counts of T lymphocytes carrying the CD4 antigen were approximately 50% of the lower limits of normal; later the counts of T lymphocytes carrying the CD3 and CD8 antigens decreased as well. By 7 weeks after resolution of the pneumonia, CD3+, CD4+ and CD8+ cell counts had returned to normal. These observations suggest that a primary transient deficiency of T cell production or maturation, especially involving CD4+ cells, may occur in otherwise normal newborn infants.
R W Hostoffer; A Litman; P G Smith; H S Jacobs; M F Tosi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  122     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-23     Completed Date:  1993-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  792-4     Citation Subset:  AIM; IM; X    
Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
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MeSH Terms
Antigens, CD4
Infant, Newborn
Leukocyte Count
Pneumonia, Pneumocystis / immunology*
T-Lymphocytes* / immunology
Reg. No./Substance:
0/Antigens, CD4

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