Document Detail

Pneumocystis carinii pneumonia in patients with Diamond-Blackfan anemia receiving high-dose corticosteroids.
MedLine Citation:
PMID:  12142794     Owner:  NLM     Status:  MEDLINE    
The authors describe three infants with Diamond-Blackfan anemia receiving corticosteroids who were diagnosed with Pneumocystis carinii pneumonia. Two patients exhibited intermittent neutropenia as well. Each child had been receiving relatively high doses of corticosteroids for at least 2 months, and two were having prednisone tapered when pneumonia developed. One child responded to trimethoprim/sulfamethoxazole and pentamidine, but the other two patients died. Infants with Diamond-Blackfan anemia receiving prolonged corticosteroid therapy should receive P. carinii pneumonia prophylaxis, such as trimethoprim/sulfamethoxazole, and prophylaxis should continue during corticosteroid tapering.
Winston W Huh; Joan Gill; Sujit Sheth; George R Buchanan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  24     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:    2002 Jun-Jul
Date Detail:
Created Date:  2002-07-26     Completed Date:  2002-08-16     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  410-2     Citation Subset:  IM    
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, 75390-9063, USA.
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MeSH Terms
Anemia, Diamond-Blackfan / complications,  drug therapy*
Anti-Infective Agents / administration & dosage,  therapeutic use
Antifungal Agents / therapeutic use
Drug Therapy, Combination
Fatal Outcome
Glucocorticoids / administration & dosage*
Immunocompromised Host
Methylprednisolone / administration & dosage
Pentamidine / therapeutic use
Pneumonia, Pneumocystis / drug therapy,  etiology*
Prednisone / administration & dosage
Trimethoprim-Sulfamethoxazole Combination / therapeutic use
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antifungal Agents; 0/Glucocorticoids; 100-33-4/Pentamidine; 53-03-2/Prednisone; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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