| Pneumocystis carinii pneumonia in critically ill patients with malignancy: a descriptive study. | |
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MedLine Citation:
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PMID: 12355379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are few data on Pneumocystis carinii pneumonia (PCP) in critically ill human immunodeficiency virus (HIV)-negative patients. Improved knowledge of the presenting symptoms of and prognostic factors for PCP may help to reduce the high mortality rate associated with PCP in such patients. We retrospectively studied 39 consecutive patients with acute PCP-related respiratory failure and malignancy who were treated at 2 intensive care units (ICUs) during a 10-year period. Univariate logistic regression identified the following 8 predictors of mortality at 30 days after patient admission to the ICU (30-day mortality rate, 33%): complete remission of the malignancy (odds ratio [OR], 0.18), receipt of >1 course of antimalignancy chemotherapy (OR, 17.2), involvement of 4 lobes noted on a chest radiograph (OR, 5), >15% neutrophils in bronchoalveolar lavage [BAL] fluid specimens (OR, 6), Organ System Failure score (OR, 7.33), Simplified Acute Physiology Score II (OR, 1.12), and the need for either mechanical ventilation (OR, 63) or vasopressors (OR, 25.9). Studies are needed to determine whether aggressive monitoring and treatment of patients with >15% neutrophils in BAL fluid specimens can improve the outcome of critically ill patients with malignancy and PCP. |
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Authors:
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J R Zahar; M Robin; E Azoulay; F Fieux; G Nitenberg; B Schlemmer |
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Publication Detail:
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Type: Journal Article Date: 2002-09-23 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 35 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-30 Completed Date: 2002-10-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 929-34 Citation Subset: IM |
Affiliation:
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Intensive Care Department, Institut Gustave-Roussy, Paris, France. jrzahar@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Critical Illness Female Humans Male Middle Aged Neoplasms / complications*, radiography Pneumonia, Pneumocystis / etiology*, radiography Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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