Document Detail

Pneumococcus-induced granulocytopenia and pulmonary leukostasis in rabbits.
MedLine Citation:
PMID:  7452094     Owner:  NLM     Status:  MEDLINE    
Mortality associated with pneumococcal disease often remains unexplained. Intraperitoneal inoculation of live PNCs into rabbits induced significant granulocytopenia compared with broth-injected controls (p < 0.001). Lung sections from the infected rabbits had significantly increased mean alveolar septal wall granulocytes compared with controls (p < 0.01). Granulocytopenia and pulmonary leukostasis occurred only in those animals with high levels of bacteremia. Intravenous challenge of rabbits with sonified, nonviable PNCs induced a mean change of blood granulocytes of -64% compared with +124% for saline-injected controls, a difference significant at p < 0.001. Mean lung granulocytes from the PNC sonicate-challenged animals were 10.7 +/- 1.7 cells/HPF compared with 4.0 +/- 1.4 for controls, a difference significant at p < 0.001. Pulmonary vascular granulocyte plugging was found in five of six experimental animals but in none of six controls. complement-depleted animals displayed significantly less granulocytopenia (p < 0.005) and pulmonary leukostasis (p < 0.005). Therefore PNC constituents induce profound, possibly complement-mediated granulocytopenia and pulmonary leukostasis. Similar phenomena may contribute to the pulmonary dysfunction and even death associated with human pneumococcal disease.
S E Goldblum; W P Reed; R L Sopher; D L Palmer
Related Documents :
3758144 - Potential pulmonary uptake and clearance of morphine in postoperative patients.
3355004 - Unilateral lung hyperlucency after mediastinal irradiation.
2218974 - Effects of inflammation and fibrosis on pulmonary function in diffuse lung fibrosis.
8744184 - Quantitative lung perfusion scintigraphy in postoperative evaluation of congenital righ...
2605064 - Hypoplastic right retro-oesophageal aortic arch: similarities to interrupted aortic arch.
24831174 - Pulmonary hypertension in patients with advanced heart failure is associated with incre...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  97     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  278-90     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Agranulocytosis / etiology*
Cell Adhesion* / drug effects
Cell Movement / drug effects
Granulocytes / cytology
Pneumonia, Pneumococcal / complications,  physiopathology*
Polysaccharides, Bacterial / pharmacology
Pulmonary Circulation*
Streptococcus pneumoniae
Reg. No./Substance:
0/Polysaccharides, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Long-term ethanol administration and short- and long-term liver regeneration after partial hepatecto...
Next Document:  Linear age-dependent population growth with seasonal harvesting.