Document Detail


Pneumococci: immunology of the innate host response.
MedLine Citation:
PMID:  20646240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the development of vaccines and antibiotics, Streptococcus pneumoniae (the pneumococcus) continues to be a major cause of human morbidity and mortality throughout the world. In recent years our understanding of how the host innate immune system recognizes and responds to pneumococcal infection has advanced significantly. Herein, we highlight some of the key features of the innate response to the pneumococcus.
Authors:
Gavin K Paterson; Carlos J Orihuela
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-07-20
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  15     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2011-01-24     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1057-63     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors; Respirology © 2010 Asian Pacific Society of Respirology.
Affiliation:
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Animals
Complement Activation / immunology
Cytokines / immunology
Humans
Immunity, Innate
Mice
Neutrophils / immunology,  microbiology
Pneumococcal Infections / immunology*,  microbiology
Pneumococcal Vaccines / immunology
Pneumonia, Pneumococcal / immunology*,  microbiology
Receptors, Scavenger / immunology
Toll-Like Receptors / immunology
Grant Support
ID/Acronym/Agency:
AG033274/AG/NIA NIH HHS; R21 AG033274-02/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Pneumococcal Vaccines; 0/Receptors, Scavenger; 0/Toll-Like Receptors
Comments/Corrections

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