Document Detail


Pneumococcal septic shock is associated with the interleukin-10-1082 gene promoter polymorphism.
MedLine Citation:
PMID:  12746253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymorphisms in the tumor necrosis factor and interleukin-10 genes, linked to cytokine inducibility, may influence the inflammatory response to infection. We studied the biallelic interleukin-10-1082 promoter, the tumor necrosis factor-alpha-308 promoter, and the lymphotoxin-alpha polymorphisms with regard to the development of septic shock in pneumococcal infection. Sixty-nine patients with pneumococcal disease (61 patients with community-acquired pneumonia, 5 patients with meningitis, and 3 patients with pneumonia and meningitis) and 50 age-matched control subjects were included. The polymorphisms were determined by the polymerase chain reaction. In patients with pneumococcal disease, the lipopolysaccharide-stimulated tumor necrosis factor and interleukin-10 release from whole blood were measured by ELISA. Sepsis severity was documented according to standard criteria. No significant genotypic differences were seen between patients and control subjects. Thirteen of 69 patients with pneumococcal disease developed septic shock. Interleukin-10 allele G homozygous patients had the highest risk for septic shock (odds ratio of 6.1; 95% confidence interval, 1.4-27.2; corrected p = 0.024). The stimulated interleukin-10 release was highest in interleukin-10 G homozygous patients (p = 0.04). In conclusion, interleukin-10 polymorphism, associated with high interleukin-10 inducibility, might influence the outcome of pneumococcal infection via induced immunosuppression and impaired bacterial clearance.
Authors:
Bernhard M Schaaf; Florian Boehmke; Hamed Esnaashari; Ulrike Seitzer; Henning Kothe; Matthias Maass; Peter Zabel; Klaus Dalhoff
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2003-05-13
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  168     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-12     Completed Date:  2003-09-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  476-80     Citation Subset:  AIM; IM    
Affiliation:
Medizinische Klinik III, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alleles
Case-Control Studies
Community-Acquired Infections / immunology
Confidence Intervals
Female
Genotype
Homozygote
Humans
Interleukin-10 / blood,  genetics*
Lymphotoxin-alpha / genetics
Male
Meningitis, Pneumococcal / genetics,  immunology*
Middle Aged
Odds Ratio
Pneumonia, Pneumococcal / genetics,  immunology*
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics*
Prospective Studies
Risk Factors
Shock, Septic / genetics,  immunology*
Tumor Necrosis Factor-alpha / analysis,  genetics
Chemical
Reg. No./Substance:
0/Lymphotoxin-alpha; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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