Document Detail

Pneumococcal meningitis following parenteral alimentation in infants.
MedLine Citation:
PMID:  6423799     Owner:  NLM     Status:  MEDLINE    
Three young infants with protracted diarrhea and malnutrition were successfully treated by means of intravenous nutrition, which included infusions of fat emulsion (Intralipid) and of fresh frozen plasma. Three to five weeks after termination of intravenous feeding, and after full recovery, they developed pneumococcal septicemia and meningitis. One infant died, and postmortem examination showed diffuse deposition of "intravenous fat pigment" in hepatocytes and in reticuloendothelial cells. In the two infants who recovered, follow-up studies did not disclose any primary derangement of immunologic function. We propose that the infused fat may have caused a temporary depression of immunologic defense mechanisms, predisposing these infants to the pneumococcal infection; the delay in onset of the infection might be attributed to a short-lasting protective effect of fresh frozen plasma which was included in the intravenous feeding regimen.
M Berant; U Alon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  3     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-05-08     Completed Date:  1984-05-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-4     Citation Subset:  IM    
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MeSH Terms
Blood / microbiology
Diarrhea, Infantile / therapy
Fat Emulsions, Intravenous / administration & dosage
Meningitis, Pneumococcal / etiology*
Parenteral Nutrition / adverse effects*
Streptococcus pneumoniae / isolation & purification
Reg. No./Substance:
0/Fat Emulsions, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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