Document Detail

Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal surface adhesin a, pneumolysin, and pneumococcal surface protein a in children.
MedLine Citation:
PMID:  11237805     Owner:  NLM     Status:  MEDLINE    
Local antibodies probably contribute to defense against Streptococcus pneumoniae. This study examined whether pneumococcal carriage and acute otitis media (AOM) induce mucosal antibodies to potential vaccine candidates pneumococcal surface adhesin A (PsaA), pneumolysin (Ply), and pneumococcal surface protein A (PspA). IgA to all 3 proteins was detected by EIA in saliva of 329 children at ages 6, 12, 18, and 24 months and of 17 adults. A higher proportion of IgA-positive samples and higher antibody concentrations were seen in children with pneumococci-positive cultures of nasopharyngeal samples or middle ear fluid than in children with all cultures negative for pneumococci. The strong correlation between IgA and the presence of the secretory component suggests that the IgA was secretory. The findings indicate that pneumococcal carriage and AOM induce local production of anti-PsaA, anti-Ply, and anti-PspA antibodies early in life.
B Simell; M Korkeila; H Pursiainen; T M Kilpi; H Käyhty
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2001-02-21
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  183     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  887-96     Citation Subset:  AIM; IM    
Department of Vaccines, National Public Health Institute, Helsinki, Finland.
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MeSH Terms
Acute Disease
Adhesins, Bacterial
Age Factors
Antibodies, Bacterial / biosynthesis*
Antigens, Bacterial / immunology
Bacterial Proteins / immunology
Carrier Proteins / immunology
Child, Preschool
Immunoglobulin A, Secretory / biosynthesis*
Lipoproteins / immunology
Membrane Transport Proteins*
Otitis Media / immunology*,  microbiology
Pneumococcal Infections / immunology*,  microbiology
Saliva / immunology*
Secretory Component / biosynthesis
Streptococcus pneumoniae / immunology*,  isolation & purification
Streptolysins / immunology
Reg. No./Substance:
0/Adhesins, Bacterial; 0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Bacterial Proteins; 0/Carrier Proteins; 0/Immunoglobulin A, Secretory; 0/Lipoproteins; 0/Membrane Transport Proteins; 0/PsaA protein, Streptococcus; 0/Secretory Component; 0/Streptolysins; 0/plY protein, Streptococcus pneumoniae; 0/pneumococcal surface protein A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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