Document Detail


Pneumococcal carriage at age 2 months is associated with growth deficits at age 6 months among infants in South India.
MedLine Citation:
PMID:  22535764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nasopharyngeal colonization is the first step in the pathway to Streptococcus pneumoniae (Spn) infection, a leading cause of childhood morbidity and mortality. We investigated the effect of Spn colonization at ages 2 and 4 mo on growth at age 6 mo among 389 infants living in rural South India by using data from an Spn carriage study nested within a randomized, double-blind, placebo-controlled community trial designed to evaluate the impact of newborn vitamin A supplementation on Spn carriage in the first 6 mo of life. Primary outcomes were weight, length, and anthropometric indices of nutritional status. Growth data at age 6 mo were available for 84% (389 of 464) of infants in the Spn carriage study. Carriage at age 2 mo was associated with increased odds of stunting [OR: 3.07 (95% CI: 1.29, 7.36) P = 0.012] and lower weight [β: -266 g (95% CI: -527, -5) P = 0.045], length [β: -1.31 cm (95% CI: -2.32, -0.31) P = 0.010], and length-for-age Z scores [β: -0.59; (95% CI: -1.05, -0.13) P = 0.012] at age 6 mo. Spn carriage at age 4 mo did not affect growth. Carriage of invasive serotypes at age 2 mo was associated with decreases in mean weight [β: -289 g; (95% CI: -491, -106) P = 0.002] and length [β:-0.38 cm (95% CI: -1.49, -0.01) P = 0.047] at age 6 mo. Newborn vitamin A supplementation did not modify the association between Spn carriage and growth. Results suggest that pneumococcal carriage at age 2 mo is an independent risk factor for poor growth in young infants. Future studies need to clarify the role of Spn carriage on growth retardation in low-income countries.
Authors:
Christian L Coles; Lakshmi Rahmathullah; Reba Kanungo; Joanne Katz; Debora Sandiford; Sheela Devi; R D Thulasiraj; James M Tielsch
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-04-25
Journal Detail:
Title:  The Journal of nutrition     Volume:  142     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-07-25     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1088-94     Citation Subset:  IM    
Affiliation:
Department of International Health, Bloomberg School of Public Health, Baltimore, MD, USA. ccoles@jhsph.edu
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MeSH Terms
Descriptor/Qualifier:
Aging
Carrier State / epidemiology*,  microbiology
Dietary Supplements
Female
Growth Disorders / epidemiology,  etiology*
Humans
India / epidemiology
Infant
Male
Nasopharynx / microbiology*
Pneumococcal Infections / epidemiology*,  prevention & control
Serotyping
Streptococcus pneumoniae / classification,  isolation & purification*
Vitamin A / administration & dosage
Vitamins / administration & dosage,  pharmacology
Grant Support
ID/Acronym/Agency:
K01DK07578/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Vitamins; 11103-57-4/Vitamin A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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