Document Detail

Pneumatosis intestinalis associated with immune-suppressive agents in a case of minimal change disease.
MedLine Citation:
PMID:  12402387     Owner:  NLM     Status:  MEDLINE    
We report treatment of a 38-year-old man with minimal change disease (MCD) who developed pneumatosis intestinalis (PI) during administration of immune-suppressive agents. His immunosuppressive medication had been tapered to 15 mg/day of prednisolone. MCD was steroid-resistant type. Abdominal examination and laboratory studies were not clinically remarkable. Radiologic findings were consistent with PI. Abnormal air accumulation was noted in the bowel, peritoneum, mediastinum and retroperitoneum. Conservative therapy with oxygen and metronidazole improved the PI symptoms. In 1993, a case of PI with nephrotic syndrome following steroid treatment was reported in Japan. However this is only the second case reported in the literature, and the first in English.
Byoung Geun Han; Jae Myoung Lee; Jae Won Yang; Min Soo Kim; Seung Ok Choi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Yonsei medical journal     Volume:  43     ISSN:  0513-5796     ISO Abbreviation:  Yonsei Med. J.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-28     Completed Date:  2002-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0414003     Medline TA:  Yonsei Med J     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  686-9     Citation Subset:  IM    
Department of Nephrology, Yonsei University Wonju College of Medicine, Korea.
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MeSH Terms
Immunosuppressive Agents / adverse effects*
Nephrosis, Lipoid / drug therapy*
Pneumatosis Cystoides Intestinalis / chemically induced*
Prednisolone / adverse effects*
Reg. No./Substance:
0/Immunosuppressive Agents; 50-24-8/Prednisolone

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