| Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury. | |
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MedLine Citation:
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PMID: 22546002 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We compared the use of bovine serum albumin (BSA) and Pluronic F108 (PF108) as dispersants for multi-walled carbon nanotubes (MWCNTs) in terms of tube stability as well as pro-fibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could be served as a safer design approach for MWCNTs. |
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Authors:
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Xiang Wang; Tian Xia; Matthew C Duch; Zhaoxia Ji; Haiyuan Zhang; Ruibin Li; Bingbing Sun; Sijie Lin; Huan Meng; Yu-Pei Liao; Meiying Wang; Tze-Bin Song; Yang Yang; Mark C Hersam; Andre E Nel |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-30 |
Journal Detail:
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Title: Nano letters Volume: - ISSN: 1530-6992 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-5-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088070 Medline TA: Nano Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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