Document Detail


Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury.
MedLine Citation:
PMID:  22546002     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We compared the use of bovine serum albumin (BSA) and Pluronic F108 (PF108) as dispersants for multi-walled carbon nanotubes (MWCNTs) in terms of tube stability as well as pro-fibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could be served as a safer design approach for MWCNTs.
Authors:
Xiang Wang; Tian Xia; Matthew C Duch; Zhaoxia Ji; Haiyuan Zhang; Ruibin Li; Bingbing Sun; Sijie Lin; Huan Meng; Yu-Pei Liao; Meiying Wang; Tze-Bin Song; Yang Yang; Mark C Hersam; Andre E Nel
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-30
Journal Detail:
Title:  Nano letters     Volume:  -     ISSN:  1530-6992     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-5-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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