Document Detail


Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury.
MedLine Citation:
PMID:  22546002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.
Authors:
Xiang Wang; Tian Xia; Matthew C Duch; Zhaoxia Ji; Haiyuan Zhang; Ruibin Li; Bingbing Sun; Sijie Lin; Huan Meng; Yu-Pei Liao; Meiying Wang; Tze-Bin Song; Yang Yang; Mark C Hersam; André E Nel
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-05-04
Journal Detail:
Title:  Nano letters     Volume:  12     ISSN:  1530-6992     ISO Abbreviation:  Nano Lett.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-13     Completed Date:  2012-10-15     Revised Date:  2014-08-27    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3050-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Coated Materials, Biocompatible / chemistry*
Lysosomes / drug effects*,  pathology*
Mice
Nanotubes, Carbon / toxicity*
Poloxamer / chemistry*
Pulmonary Fibrosis / chemically induced*,  pathology,  prevention & control*
Grant Support
ID/Acronym/Agency:
R01 ES016746/ES/NIEHS NIH HHS; R01 ES016746/ES/NIEHS NIH HHS; U19 ES019528/ES/NIEHS NIH HHS; U19 ES019528/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Nanotubes, Carbon; 106392-12-5/Poloxamer
Comments/Corrections

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