| Plurichemical transmission and chemical coding of neurons in the digestive tract. | |
| | |
MedLine Citation:
|
PMID: 7835599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The enteric nervous system contains neurons with well-defined functions. However, when neurons of the same function are examined in different regions or species, they are found to show subtle differences in their pharmacologies of transmission and different chemical coding. Individual enteric neurons use more than one transmitter, i.e., transmission is plurichemical. For example, enteric inhibitory neurons have three or more primary transmitters, including nitric oxide, vasoactive intestinal peptide, and possibly adenosine triphosphate and pituitary adenylyl cyclase activating peptide. Primary transmitters are highly conserved, although their relative roles vary considerably between gut regions. Multiple substances, including transmitters and their synthesizing enzymes and nontransmitters (such as neurofilament proteins), provide neurons with a chemical coding through which their functions and projections can be identified. Although equivalent neurons in different regions have the same primary transmitters, other chemical markers differ substantially. Caution must be taken in extrapolating pharmacological and neurochemical observations between species or even between regions in the one species. On the other hand, careful interregion and interspecies comparisons lead to an understanding of the features of enteric neurons that are highly conserved and can be used in valid extrapolation. |
| | |
Authors:
|
J B Furness; H M Young; S Pompolo; J C Bornstein; W A Kunze; K McConalogue |
Related Documents
:
|
15609089 - Distribution of neuronal nitric oxide synthase-immunoreactive neurons in the cerebral c... 3143749 - Markers shared between dorsal root and enteric ganglia. 1928749 - The efferent projections of neurons in the white matter of different cortical areas of ... 9200749 - Co-localization of vasoactive intestinal polypeptide, gamma-aminobutyric acid and choli... 9100259 - Upregulation of nicotinamide adenine dinucleotide phosphate-diaphorase reactivity in th... 6371579 - Localization of neurons containing immunoreactive delta sleep-inducing peptide in the r... 3768719 - Saving-effect of stimulating pulses at low-frequency amygdaloid kindling in cats. 6168669 - Organization of corticothalamic projections from parietal cortex in cat. 12902309 - Depletion of ventromedullary nk-1 receptor-immunoreactive neurons in multiple system at... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Gastroenterology Volume: 108 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1995 Feb |
Date Detail:
|
Created Date: 1995-03-01 Completed Date: 1995-03-01 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 554-63 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Digestive System / innervation* Humans Motor Neurons / chemistry*, physiology Neurotransmitter Agents / physiology* Synaptic Transmission / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
NS 23816/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Human papillomavirus type 16-positive esophageal papilloma at an endoscopic injection sclerotherapy ...
Next Document: The changing relative prevalence of hepatitis C virus genotypes: evidence in hemodialyzed patients a...