Document Detail


Plurichemical transmission and chemical coding of neurons in the digestive tract.
MedLine Citation:
PMID:  7835599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The enteric nervous system contains neurons with well-defined functions. However, when neurons of the same function are examined in different regions or species, they are found to show subtle differences in their pharmacologies of transmission and different chemical coding. Individual enteric neurons use more than one transmitter, i.e., transmission is plurichemical. For example, enteric inhibitory neurons have three or more primary transmitters, including nitric oxide, vasoactive intestinal peptide, and possibly adenosine triphosphate and pituitary adenylyl cyclase activating peptide. Primary transmitters are highly conserved, although their relative roles vary considerably between gut regions. Multiple substances, including transmitters and their synthesizing enzymes and nontransmitters (such as neurofilament proteins), provide neurons with a chemical coding through which their functions and projections can be identified. Although equivalent neurons in different regions have the same primary transmitters, other chemical markers differ substantially. Caution must be taken in extrapolating pharmacological and neurochemical observations between species or even between regions in the one species. On the other hand, careful interregion and interspecies comparisons lead to an understanding of the features of enteric neurons that are highly conserved and can be used in valid extrapolation.
Authors:
J B Furness; H M Young; S Pompolo; J C Bornstein; W A Kunze; K McConalogue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  108     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-01     Completed Date:  1995-03-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  554-63     Citation Subset:  AIM; IM    
Affiliation:
Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Digestive System / innervation*
Humans
Motor Neurons / chemistry*,  physiology
Neurotransmitter Agents / physiology*
Synaptic Transmission / physiology*
Grant Support
ID/Acronym/Agency:
NS 23816/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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