| Plurality-dependent risk of respiratory distress syndrome among very-low-birth-weight infants and antepartum corticosteroid treatment. | |
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MedLine Citation:
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PMID: 15695972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to determine the effect of antenatal corticosteroids on the incidence of respiratory distress syndrome in singleton infants and multiple infants who weigh <1500 g and are delivered at 24 to 32 weeks of gestation. STUDY DESIGN: The incidence of respiratory distress syndrome was established in 4754 singleton infants, 2460 twin infants, and 906 triplet infants. RESULTS: The incidence of respiratory distress syndrome ranged from 58.2% among singleton infants who received a complete course of antenatal corticosteroid to 81.5% in triplets without any treatment. Complete treatment significantly reduced the incidence of respiratory distress syndrome, compared with partial or no treatment (odds ratio, 0.2-0.6). The adjusted risk for respiratory distress syndrome among infants who received a complete course of antenatal corticosteroids compared with singleton infants increased with plurality (odds ratio, 1.4 and 1.8 for twins and triplets, respectively). CONCLUSION: The effect of corticosteroids decreased with increasing plurality. Irrespective of plurality, a complete course of antenatal corticosteroids significantly reduced the incidence of respiratory distress syndrome, whereas partial treatment had the same effect as no treatment. |
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Authors:
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Isaac Blickstein; Eric S Shinwell; Ayala Lusky; Brian Reichman; |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 192 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-02-07 Completed Date: 2005-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 360-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology,Kaplan Medical Center, Rehovot and the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel. blick@netvision.net.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use* Humans Infant, Newborn Infant, Very Low Birth Weight Odds Ratio Respiratory Distress Syndrome, Newborn / epidemiology, prevention & control* Risk Triplets* Twins* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 2006 Jan;194(1):302; author reply 302
[PMID:
16389052
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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