| Plugging PKA into ERK scaffolds. | |
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MedLine Citation:
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PMID: 21311231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cancers often arise in part through derangements in protein kinase signaling. A striking example of this is the finding that approximately 30% of human tumors have mutations in Ras or B-Raf, leading to aberrant ERK kinase activation. Kinase signaling networks are often organized by scaffolding and anchoring proteins that help shape the dynamics of signal processing. AKAP-Lbc associates with the ERK scaffold protein KSR-1 to organize a growth factor and cAMP responsive signaling network. AKAP-Lbc also directs PKA phosphorylation of KSR-1 on a critical residue to ensure maximal signaling efficiency. |
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Authors:
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F Donelson Smith; Lorene K Langeberg; John D Scott |
Publication Detail:
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Type: Editorial; Research Support, Non-U.S. Gov't Date: 2011-03-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 10 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-07 Completed Date: 2011-06-27 Revised Date: 2012-11-01 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 731-2 Citation Subset: IM |
Copyright Information:
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© 2011 Landes Bioscience |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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A Kinase Anchor Proteins
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metabolism Animals Cyclic AMP-Dependent Protein Kinases / metabolism* Extracellular Signal-Regulated MAP Kinases / metabolism* Humans Mice Phosphorylation Protein Kinases / metabolism Signal Transduction ras Proteins / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 DK054441/DK/NIDDK NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/A Kinase Anchor Proteins; EC 2.7.-/Protein Kinases; EC 2.7.1.-/KSR-1 protein kinase; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases; EC 3.6.5.2/ras Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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