Document Detail

Plugging PKA into ERK scaffolds.
MedLine Citation:
PMID:  21311231     Owner:  NLM     Status:  MEDLINE    
Cancers often arise in part through derangements in protein kinase signaling. A striking example of this is the finding that approximately 30% of human tumors have mutations in Ras or B-Raf, leading to aberrant ERK kinase activation. Kinase signaling networks are often organized by scaffolding and anchoring proteins that help shape the dynamics of signal processing. AKAP-Lbc associates with the ERK scaffold protein KSR-1 to organize a growth factor and cAMP responsive signaling network. AKAP-Lbc also directs PKA phosphorylation of KSR-1 on a critical residue to ensure maximal signaling efficiency.
F Donelson Smith; Lorene K Langeberg; John D Scott
Publication Detail:
Type:  Editorial; Research Support, Non-U.S. Gov't     Date:  2011-03-01
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  10     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-06-27     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  731-2     Citation Subset:  IM    
Copyright Information:
© 2011 Landes Bioscience
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MeSH Terms
A Kinase Anchor Proteins / metabolism
Cyclic AMP-Dependent Protein Kinases / metabolism*
Extracellular Signal-Regulated MAP Kinases / metabolism*
Protein Kinases / metabolism
Signal Transduction
ras Proteins / genetics,  metabolism
Grant Support
P01 DK054441/DK/NIDDK NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/A Kinase Anchor Proteins; EC 2.7.-/Protein Kinases; EC 2.7.1.-/KSR-1 protein kinase; EC AMP-Dependent Protein Kinases; EC Signal-Regulated MAP Kinases; EC Proteins

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