| The Plk3-Cdc25 circuit. | |
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MedLine Citation:
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PMID: 15640846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polo-like kinases (Plks) are key regulators of the cell cycle, especially in the G2 phase and mitosis. They are incorporated into signaling networks that regulate many aspects of the cell cycle, including but not limited to centrosome maturation and separation, mitotic entry, chromosome segregation, mitotic exit, and cytokinesis. The Plks have well conserved 30-amino-acid elements, designated polo boxes (PBs), located in their carboxyl-termini, which with their flanking regions constitute a functional Polo-box domain (PBD). Members of the Plk family exist in a variety of organisms including Polo in Drosophila melanogaster; Cdc5 in Saccharomyces cerevisiae; Plo1 in Schizosaccharomyces pombe; Plx1 in Xenopus laevis; and Plk1, Snk/Plk2, Fnk/Prk/Plk3, and Sak in mammals. Polo, Cdc5, and Plo1 are essential for viability. The Plks can be separated into two groups according to their functions. The first group (Polo, Cdc5, plo1, Plx1, and Plk1) primarily performs mitotic functions, whereas the second group (Plk2 and Plk3) appears to have additional functions during the G1, S, and G2 phases of the cell cycle. Several contributions to this issue will discuss different aspects of Plk involvement in cell-cycle regulation. This review, therefore, will focus on the role of Plk3 in regulating Cdc25 phosphatase function and its effect on the cell cycle. |
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Authors:
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David L Myer; El Mustapha Bahassi; Peter J Stambrook |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Oncogene Volume: 24 ISSN: 0950-9232 ISO Abbreviation: Oncogene Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-10 Completed Date: 2005-02-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: England |
Other Details:
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Languages: eng Pagination: 299-305 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle Proteins / physiology* Humans Mitosis / physiology Protein-Serine-Threonine Kinases / physiology* Xenopus Proteins / physiology cdc25 Phosphatases / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P30 ES05652/ES/NIEHS NIH HHS; P30-ES06096/ES/NIEHS NIH HHS; R01 CA90934/CA/NCI NIH HHS; T32 ES07250/ES/NIEHS NIH HHS; U01 ES011038/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Xenopus Proteins; EC 2.7.1.-/Cnk protein, rat; EC 2.7.1.-/PLK3 protein, human; EC 2.7.1.-/Plk3 protein, mouse; EC 2.7.1.-/Plx3 protein, Xenopus; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 3.1.3.16/Cdc25a protein, mouse; EC 3.1.3.48/CDC25A protein, human; EC 3.1.3.48/CDC25C protein, human; EC 3.1.3.48/Cdc25a protein, rat; EC 3.1.3.48/Cdc25c protein, mouse; EC 3.1.3.48/cdc25 Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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