Document Detail

Plexiform Fibromyxoma: Report of Two Pediatric Cases, Including the First Example in the Esophagus.
MedLine Citation:
PMID:  24160555     Owner:  NLM     Status:  Publisher    
Abstract Plexiform fibromyxoma is a distinctive mesenchymal neoplasm usually arising in the gastric antrum. We report two cases of this entity in pediatric patients, including the first case arising in the esophagus. The patients were a 16-year-old female who presented with chest pain and was found on CT scan to have a mid-esophageal mass at the level of the carina, and an 11-year-old female with a gastric mass. Both patients underwent surgical resection of their tumors, which histologically exhibited a plexiform growth pattern with multiple nodules in the muscularis propria and infiltrative borders. The nodules were composed of a rich myxoid stroma with bland uniform spindle cells, no mitoses or necrosis, and delicate blood vessels in the background. Immunohistochemical studies demonstrated the tumor cells were immunoreactive with smooth muscle actin, and negative with S-100, CD34, desmin, and c-kit. We report the first case of plexiform fibromyxoma originating in the esophagus, emphasize its occurrence in pediatric patients, and review the related literature.
Lizette Vila Duckworth; Raul S Gonzalez; Matthew Martelli; Chen Liu; Cheryl M Coffin; John Reith
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-25
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a University of Florida, Pathology, Immunology, and Laboratory Medicine.
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