Document Detail


Pleuropulmonary disease due to pergolide use for restless legs syndrome.
MedLine Citation:
PMID:  11451859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pergolide is an ergot-derived dopamine agonist used in Parkinson's disease and, increasingly, in restless legs syndrome. We report a patient with a 2.5-year history of weight loss, pleuropulmonary fibrosis, and exudative pleural effusion that developed insidiously while taking this medication. The extensive and invasive workup that preceded the diagnosis highlights the difficulty in attributing such a process to a drug reaction. This is the second report of such a reaction to pergolide, which is one of the increasing number of ergot-derived compounds in common clinical use.
Authors:
S K Danoff; M E Grasso; P B Terry; J A Flynn
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  120     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-13     Completed Date:  2001-08-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  313-6     Citation Subset:  AIM; IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Dopamine Agonists / adverse effects*,  therapeutic use
Fibrosis
Humans
Male
Pergolide / adverse effects*,  therapeutic use
Pleural Diseases / chemically induced*,  diagnosis
Pleural Effusion / chemically induced
Pulmonary Fibrosis / chemically induced*,  diagnosis
Restless Legs Syndrome / drug therapy*
Chemical
Reg. No./Substance:
0/Dopamine Agonists; 66104-22-1/Pergolide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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