Document Detail

Pleuro-pulmonary endometriosis in baboons (Papio spp.): insights into pathogenesis.
MedLine Citation:
PMID:  23198871     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Human pleuro-pulmonary endometriosis (PPE) is rare. Recently, we identified several cases of abdominal endometriosis in baboons that developed PPE.
MATERIALS AND METHODS: Ten cases of PPE and four of intra-abdominal endometriosis (three simultaneous) were identified at necropsy in baboons (Papio spp.) found dead due to natural causes. The endometriotic lesions were evaluated using immunohistochemistry.
RESULTS: The stromal (CD10+) and epithelial cells in intra-abdominal cases were estrogen and progesterone receptor (ER/PR) positive and thyroid transcription factor 1 (TTF-1) negative similar to that seen in humans. In contrast, the PPE cases displayed TTF-1-positive epithelium lining the cystic spaces, while the stroma was ER/PR positive similar to that in abdominal endometriosis. Both lymph nodes and spindle cell rests in lung interstitium contained ER/PR-positive stromal cells.
CONCLUSIONS: The lung lesions were different from the abdominal lesions in having a TTF-1-positive lining epithelium. The deep pulmonary interstitial and lymph node endometrial stromal rests probably arrive via lymphatic route. The endometrial stroma is the driving force in PPE upon which the lung-specific epithelium condenses and may require a novel approach to therapy.
J Jagirdar; D Sirohi; E J Dick; G Hubbard
Publication Detail:
Type:  Journal Article     Date:  2012-12-01
Journal Detail:
Title:  Journal of medical primatology     Volume:  42     ISSN:  1600-0684     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-06-10     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Endometriosis / classification,  pathology,  veterinary*
Lung Diseases / pathology,  veterinary*
Monkey Diseases / pathology*
Pleural Diseases / pathology,  veterinary*
Grant Support
P51 OD011133/OD/NIH HHS; P51 RR013986/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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