Document Detail

Pleuric presentation of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: a case report and a review of the literature.
MedLine Citation:
PMID:  20725816     Owner:  NLM     Status:  MEDLINE    
A primary pleural marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT) is a very rare eventuality. Here, we report a rare case of MALT lymphoma arising in the pleura and update the literature on this topic. A 74-year-old female was hospitalized for persistent cough and weakness. A chest radiograph and total-body CT scan showed only large right-sided pleural effusion, and the coexistence of pleural thickening. Video-assisted thoracoscopic exploration and a talc pleurodesis were performed and microscopic and immunohistochemical findings showed that the tumor was a pleural MALT lymphoma. The patient received immunotherapy with Rituximab and obtained a good response that lasted 2 years. To the best of our knowledge, only seven cases of primary pleural MALT lymphoma have been documented until recently, mostly from Japan with a mean age for all patients of 60.5 years. The pathogenesis of MALT lymphomas remains unclear, although a possible chronic antigenic stimulation by microbial pathogens and/or autoantigens has been hypothesized. Surgical resection was performed in most cases, and some patients received postoperative chemotherapy or immunotherapy. The clinicopathologic characteristics and management of this extremely rare disease are also discussed.
Giovanna Motta; Concetta Conticello; Gabriella Amato; Gaetano Moschetti; Cristina Colarossi; Sebastiano Cosentino; Massimo Ippolito; Rosario Giustolisi; Francesco Di Raimondo
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-08-20
Journal Detail:
Title:  International journal of hematology     Volume:  92     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  369-73     Citation Subset:  IM    
Department of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande, Catania, Italy.
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MeSH Terms
Antibodies, Monoclonal, Murine-Derived / therapeutic use
Antineoplastic Agents
Lymphoma, B-Cell, Marginal Zone / diagnosis*,  drug therapy
Pleura / pathology
Pleural Effusion / diagnosis*,  drug therapy
Remission Induction
Reg. No./Substance:
0/Antibodies, Monoclonal, Murine-Derived; 0/Antineoplastic Agents; 0/rituximab

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