Document Detail

Pleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors.
MedLine Citation:
PMID:  21258363     Owner:  NLM     Status:  MEDLINE    
Immunosuppressive mediators in tuberculosis pleurisy (pleural fluid (PF)) are associated with the course of disease, but they remain poorly defined. To study the local immune status of patients with tuberculosis pleurisy, we examined the effect of PF on the functions of T cells and the differentiation of Th1 cells. PF could inhibit the ability of T cells to produce cytokines. However, tumor-necrosis factor (TNF)-α derived from non-T cells was not impaired. Further analysis indicated that cell activation and cell cycle progression were also suppressed. Moreover, PF could inhibit Th1 cell differentiation. Importantly, we found that inhibitors of indoleamine 2,3-dioxygenase (IDO) and adenosine and neutralizing antibodies against IL-10 and transforming growth factor (TGF)-β could reverse cytokine production, suggesting that IDO, adenosine, IL-10 and Transforming growth factor-β1 in PF might take part in impairing T-cell functions. Taken together, our data demonstrate for the first time that several immunopathological factors participate in the downregulation of T-cell functions in local PF.
Qin Li; Li Li; Yun Liu; Xiaoying Fu; Dan Qiao; Hui Wang; Suihua Lao; Fengyu Huang; Changyou Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-24
Journal Detail:
Title:  Cellular & molecular immunology     Volume:  8     ISSN:  2042-0226     ISO Abbreviation:  Cell. Mol. Immunol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-08     Completed Date:  2011-07-26     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  101242872     Medline TA:  Cell Mol Immunol     Country:  China    
Other Details:
Languages:  eng     Pagination:  172-80     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Body Fluids / immunology*
CD8-Positive T-Lymphocytes / immunology
Cell Cycle
Cell Differentiation / immunology*
Cytokines / biosynthesis
Immunosuppressive Agents / immunology*
Lymphocyte Activation / immunology
Middle Aged
Signal Transduction
Th1 Cells / immunology*,  pathology*
Tuberculosis, Pleural / immunology*
Young Adult
Reg. No./Substance:
0/Cytokines; 0/Immunosuppressive Agents

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