Document Detail


Pleural function and lymphatics.
MedLine Citation:
PMID:  23009260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pleural space plays an important role in respiratory function as the negative intrapleural pressure regimen ensures lung expansion and in the mean time maintains the tight mechanical coupling between the lung and the chest wall. The efficiency of the lung-chest wall coupling depends upon pleural liquid volume, which in turn reflects the balance between the filtration of fluid into and its egress out of the cavity. While filtration occurs through a single mechanism passively driving fluid from the interstitium of the parietal pleura into the cavity, several mechanisms may co-operate to remove pleural fluid. Among these, the pleural lymphatic system emerges as the most important one in quantitative terms and the only one able to cope with variable pleural fluid volume and drainage requirements. In this review, we present a detailed account of the actual knowledge on: (a) the complex morphology of the pleural lymphatic system, (b) the mechanism supporting pleural lymph formation and propulsion, (c) the dependence of pleural lymphatic function upon local tissue mechanics and (d) the effect of lymphatic inefficiency in the development of clinically severe pleural and, more in general, respiratory pathologies.
Authors:
D Negrini; A Moriondo
Publication Detail:
Type:  Journal Article; Review     Date:  2012-10-17
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  207     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-09     Completed Date:  2013-07-22     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  244-59     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Lymphatic System* / anatomy & histology,  physiology
Pleura* / anatomy & histology,  physiology
Pleural Cavity* / anatomy & histology,  physiology
Comments/Corrections
Comment In:
Acta Physiol (Oxf). 2014 Sep;212(1):6-7   [PMID:  25041630 ]
Acta Physiol (Oxf). 2014 Sep;212(1):5   [PMID:  24947653 ]

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