Document Detail


Pleomorphic xanthoastrocytoma of the spinal cord: case report and literature review.
MedLine Citation:
PMID:  24495348     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pleomorphic xanthoastrocytoma (PXA) is a rare slow-growing neoplasm that has predilection for the supratentorial compartment and the temporal lobe. Children and young adults are most frequently affected and they usually present with medically refractory seizures. PXAs involving the spinal cord have been rarely documented. We describe a 15-year-old boy who presented with shoulder/neck pain and upper extremity numbness/weakness. Neuroimaging revealed a solid, contrast enhancing, and intramedullary C5 - C6 mass. Microscopy demonstrated a typical WHO grade II PXA. Molecular testing did not reveal a BRAF V600E, IDH1 R132H, or IDH2 R172H mutation. Two years after a near total resection, significant tumor progression was noted via neuroimaging. To the authors' knowledge, this is the first description of the molecular characteristics of a spinal cord PXA.
Authors:
Sumit Das; Stephen Yip; Juliette Hukin; Douglas Cochrane; Christopher Dunham
Related Documents :
7892158 - Angiosarcoma developing from chronic pyothorax.
6821828 - Angioimmunoblastic lymphadenopathy. a case with an unusual clinical course with marked ...
1401348 - Pigmented malignant pilomatrixoma: report of a case and review of the literature.
6360328 - Malignant melanoma metastatic to the cystic and common bile ducts.
24515868 - Eosinophilic granulomatosis with polyangiitis complicated by cholecystitis: a case repo...
1784468 - Inherited corneal amyloidosis predominantly manifested in one eye.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-5
Journal Detail:
Title:  Clinical neuropathology     Volume:  -     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early Diagnosis and Treatment of a Posttraumatic Pseudoaneurysm/Dissection of the Innominate Artery.
Next Document:  Leptin gene promoter DNA methylation in WNIN obese mutant rats.