Document Detail


Pleiotropic effects of inhibitors of the RAAS in the diabetic population: above and beyond blood pressure lowering.
MedLine Citation:
PMID:  20425064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are indispensable therapeutic agents for treating hypertension and proteinuria in patients with diabetes mellitus. Studies have shown that the renin-angiotensin-aldosterone system (RAAS) has effects on various organ systems, including the central nervous system, heart, and kidneys. Angiotensin II has major deleterious effects on vascular compliance, vascular relaxation, and plasma markers of inflammation, which are surrogate markers of cardiovascular disease. Evidence is established from major trials that ACE inhibitors and ARB therapy improve these surrogate markers and reduce cardiovascular disease, renal disease, and stroke. Accumulating evidence also supports the newer class of medication, the direct renin inhibitor aliskiren, as beneficial in hypertensive persons with diabetes mellitus. In this article, we review the mechanisms through which inhibitors of the RAAS benefit persons with hypertension and decrease the development of cardiovascular and renal disease above and beyond blood pressure lowering.
Authors:
Haisam Ismail; Rena Mitchell; Samy I McFarlane; Amgad N Makaryus
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current diabetes reports     Volume:  10     ISSN:  1539-0829     ISO Abbreviation:  Curr. Diab. Rep.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093791     Medline TA:  Curr Diab Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  IM    
Affiliation:
Department of Cardiology, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA.
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MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / pharmacology*,  therapeutic use*
Blood Pressure / drug effects*
Diabetes Complications / drug therapy,  physiopathology
Diabetes Mellitus / drug therapy*,  physiopathology
Humans
Hypertension / drug therapy,  etiology,  physiopathology
Renin-Angiotensin System / drug effects*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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