Document Detail


Pleiotropic effects of cardilopin (secondary coronary prevention).
MedLine Citation:
PMID:  15834180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to evaluate some pleiotropic effects of cardilopin (Amlodipine, EGIS Pharmaceuticals) 33 ambulatory patients were examined. During the 2-month study period on the background of cardilopin treatment there were positive changes in some parameters of coronary atherosclerosis. Pleiotropic effects of cardilopin were particularly expressed in restoring of endothelial function and inhibition of platelet aggregation. There was found tendency to reduce the degree of hyperlipoperoxidemia related to oxidative stress. Obtained results of the present trial support the use of cardilopin in all coronary heart disease patients with or without myocardial revascularization and arterial hypertension.
Authors:
S Kapanadze; N Dolidze; Z Bakhutashvili; L Chapidze; E Shengelia
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Georgian medical news     Volume:  -     ISSN:  1512-0112     ISO Abbreviation:  Georgian Med News     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-18     Completed Date:  2005-05-26     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  101218222     Medline TA:  Georgian Med News     Country:  Georgia (Republic)    
Other Details:
Languages:  eng     Pagination:  46-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amlodipine / administration & dosage,  pharmacology,  therapeutic use*
Blood Pressure / drug effects
Blood Pressure Monitors
Calcium Channel Blockers / administration & dosage,  pharmacology,  therapeutic use*
Coronary Disease / blood,  drug therapy*,  metabolism,  physiopathology
Endothelium, Vascular / physiology
Heart Rate
Humans
Lipid Peroxides / blood
Nitric Oxide / blood
Oxidative Stress
Platelet Aggregation / drug effects
Time Factors
Vasodilator Agents / administration & dosage,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Lipid Peroxides; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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